MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. - Test2 - elhamkhani - TriplyDB

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.

http://www.wikidata.org/entity/Q34016183

about

Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1 p53 mediates the negative regulation of MDM2 by orphan receptor TR3 Regulation of E2F1 function by the nuclear corepressor KAP1 Identification of novel small molecules that inhibit protein-protein interactions between MAGE and KAP-1 Trim24 targets endogenous p53 for degradation Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1 Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing KAPtain in charge of multiple missions: Emerging roles of KAP1 Regulation of TGF-β signal transduction by mono- and deubiquitylation of Smads Decreased survival and hepato-renal pathology in mice with C-terminally truncated GP73 (GOLPH2)A Novel Interaction between TFII-I and Mdm2 with a Negative Effect on TFII-I Transcriptional Activity Enhanced deacetylation of p53 by the anti-apoptotic protein HSCO in association with histone deacetylase 1.Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1.Bioinformatics analysis of the prognostic value of Tripartite Motif 28 in breast cancer A multiprotein binding interface in an intrinsically disordered region of the tumor suppressor protein interferon regulatory factor-1 Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation and autodegradation during DNA damage Cellular senescence and protein degradation: breaking down cancer The prolyl isomerase, FKBP25, interacts with RNA-engaged nucleolin and the pre-60S ribosomal subunit.Autoactivation of the MDM2 E3 ligase by intramolecular interaction.MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output Mechanism of p53 stabilization by ATM after DNA damage.Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage Making sense of ubiquitin ligases that regulate p53.Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma Inhibition of p53 DNA binding function by the MDM2 protein acidic domain.Loss of ZBRK1 contributes to the increase of KAP1 and promotes KAP1-mediated metastasis and invasion in cervical cancer.KAP1 promotes proliferation and metastatic progression of breast cancer cells Functional analysis of KAP1 genomic recruitment.Zinc fingers function cooperatively with KRAB domain for nuclear localization of KRAB-containing zinc finger proteins A pathway for the control of anoikis sensitivity by E-cadherin and epithelial-to-mesenchymal transition.Transcriptional regulation of heterogeneous nuclear ribonucleoprotein K gene expression.Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage TRIM28 Is an E3 Ligase for ARF-Mediated NPM1/B23 SUMOylation That Represses Centrosome Amplification Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response.Heterochromatin protein 1alpha: a hallmark of cell proliferation relevant to clinical oncology.

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P2860

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.

http://www.wikidata.org/entity/Q34016183

description

2005 nî lūn-bûn

@nan

2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2005年の論文

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2005年論文

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2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.

@ast

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.

@en

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.

@nl

type

label

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.

@ast

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.

@en

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.

@nl

prefLabel

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.

@ast

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.

@en

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.

@nl

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SJ.EMBOJ.7600791

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The EMBO Journal

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MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.

@en

P2093

Alexey Ivanov

http://www.w3.org/2001/XMLSchema#string

Chuangui Wang

http://www.w3.org/2001/XMLSchema#string

Ed Seto

http://www.w3.org/2001/XMLSchema#string

Frank J Rauscher

http://www.w3.org/2001/XMLSchema#string

Jiandong Chen

http://www.w3.org/2001/XMLSchema#string

Lihong Chen

http://www.w3.org/2001/XMLSchema#string

William J Fredericks

http://www.w3.org/2001/XMLSchema#string

P2860

KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing.

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions

Histone deacetylases specifically down-regulate p53-dependent gene activation

KAP-1, a novel corepressor for the highly conserved KRAB repression domain

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

MDMX: a novel p53-binding protein with some functional properties of MDM2

Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway

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3279-3290

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10.1038/SJ.EMBOJ.7600791

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18

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24

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2005-08-18T00:00:00Z

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7652538

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16107876

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1224681

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