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MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activityAntitumor Activity of a 5-Hydroxy-1H-Pyrrol-2-(5H)-One-Based Synthetic Small Molecule In Vitro and In VivoMdm2 links genotoxic stress and metabolism to p53.Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence.Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging.CHK2 kinase in the DNA damage response and beyondRegulation of the DNA damage response by ubiquitin conjugation.DNA damage response and repair: insights into strategies for radiation sensitization of gliomasCooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells.F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stressDietary NiCl₂ causes G₂/M cell cycle arrest in the broiler's kidney.Molecular targets and mechanisms of radiosensitization using DNA damage response pathways.DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destructionThe p53 Codon 72 Polymorphism Modifies the Cellular Response to Inflammatory Challenge in the LiverCr(VI) induces premature senescence through ROS-mediated p53 pathway in L-02 hepatocytes.ATM kinase activity modulates ITCH E3-ubiquitin ligase activity.ARRB1 enhances the chemosensitivity of lung cancer through the mediation of DNA damage responseBeyond ATM: the protein kinase landscape of the DNA damage response.Differential proteomics in the search for biomarkers of radiotherapy resistance.Roles of COP9 signalosome in cancer.Regulation of p53: a collaboration between Mdm2 and Mdmx.Unravelling mechanisms of cisplatin sensitivity and resistance in testicular cancer.Polo-like kinase-1 in DNA damage response.Molecular interactions of polo-like kinase 1 in human cancers.PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress.Attractor landscape analysis reveals feedback loops in the p53 network that control the cellular response to DNA damage.Knockdown of ZNF403 inhibits cell proliferation and induces G2/M arrest by modulating cell-cycle mediators.The DNA damage response pathway in normal hematopoiesis and malignancies.Principal Aspects Regarding the Maintenance of Mammalian Mitochondrial Genome Integrity.Rac1 promotes diethylnitrosamine (DEN)-induced formation of liver tumors.Arabidopsis R1R2R3-Myb proteins are essential for inhibiting cell division in response to DNA damage.ATM-mediated phosphorylation of SOG1 is essential for the DNA damage response in Arabidopsis.Efficacy of Adoptive T-cell Therapy Is Improved by Treatment with the Antioxidant N-Acetyl Cysteine, Which Limits Activation-Induced T-cell Death.BAC transgenic mice provide evidence that p53 expression is highly regulated in vivo.Loss of Genome Fidelity: Beta HPVs and the DNA Damage Response.6-Gingerol prevents MEHP-induced DNA damage in human umbilical vein endothelia cells.Anti-leukaemic effects induced by APR-246 are dependent on induction of oxidative stress and the NFE2L2/HMOX1 axis that can be targeted by PI3K and mTOR inhibitors in acute myeloid leukaemia cells.The fate of murine double minute X (MdmX) is dictated by distinct signaling pathways through murine double minute 2 (Mdm2).BTK blocks the inhibitory effects of MDM2 on p53 activity.Oxidative stress and cell cycle arrest induced by short-term exposure to dustfall PM2.5 in A549 cells.
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Mechanism of p53 stabilization by ATM after DNA damage.
@ast
Mechanism of p53 stabilization by ATM after DNA damage.
@en
Mechanism of p53 stabilization by ATM after DNA damage.
@nl
type
label
Mechanism of p53 stabilization by ATM after DNA damage.
@ast
Mechanism of p53 stabilization by ATM after DNA damage.
@en
Mechanism of p53 stabilization by ATM after DNA damage.
@nl
prefLabel
Mechanism of p53 stabilization by ATM after DNA damage.
@ast
Mechanism of p53 stabilization by ATM after DNA damage.
@en
Mechanism of p53 stabilization by ATM after DNA damage.
@nl
P2860
P356
P1433
P1476
Mechanism of p53 stabilization by ATM after DNA damage.
@en
P2093
Jiandong Chen
Qian Cheng
P2860
P304
P356
10.4161/CC.9.3.10556
P577
2010-02-01T00:00:00Z