Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance.
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In type 1 diabetes a subset of anti-coxsackievirus B4 antibodies recognize autoantigens and induce apoptosis of pancreatic beta cellsRegulation of Bim in Health and DiseaseMechanisms of Beta Cell Dysfunction Associated With Viral InfectionGLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein BimEndoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalancePKR regulates proliferation, differentiation, and survival of murine hematopoietic stem/progenitor cellsA20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes.PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim.The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cellsThe human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.Nova1 is a master regulator of alternative splicing in pancreatic beta cells.Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cellsProteomic profiling of human islets collected from frozen pancreata using laser capture microdissection.USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosisEnterovirus infection of human islets of Langerhans affects β-cell function resulting in disintegrated islets, decreased glucose stimulated insulin secretion and loss of Golgi structureThe proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicityDiabetes in Friedreich ataxia.Pancreatic pathology in type 1 diabetes mellitus.Death waits for no man--does it wait for a virus? How enteroviruses induce and control cell deathGLIS3 rs7020673 and rs10758593 polymorphisms interact in the susceptibility for type 1 diabetes mellitus.Enterovirus-induced gene expression profile is critical for human pancreatic islet destructionExpression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1
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P2860
Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance.
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2011 nî lūn-bûn
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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
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2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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Exposure to the viral by-produ ...... s via a Bim / Mcl-1 imbalance.
@ast
Exposure to the viral by-produ ...... s via a Bim / Mcl-1 imbalance.
@en
Exposure to the viral by-produ ...... s via a Bim / Mcl-1 imbalance.
@nl
type
label
Exposure to the viral by-produ ...... s via a Bim / Mcl-1 imbalance.
@ast
Exposure to the viral by-produ ...... s via a Bim / Mcl-1 imbalance.
@en
Exposure to the viral by-produ ...... s via a Bim / Mcl-1 imbalance.
@nl
prefLabel
Exposure to the viral by-produ ...... s via a Bim / Mcl-1 imbalance.
@ast
Exposure to the viral by-produ ...... s via a Bim / Mcl-1 imbalance.
@en
Exposure to the viral by-produ ...... s via a Bim / Mcl-1 imbalance.
@nl
P2093
P2860
P50
P1433
P1476
Exposure to the viral by-produ ...... s via a Bim / Mcl-1 imbalance.
@en
P2093
Anne Op de Beeck
Daniel A Cunha
Decio L Eizirik
Maikel L Colli
Merja Roivainen
Tatiane C Nogueira
P2860
P304
P356
10.1371/JOURNAL.PPAT.1002267
P577
2011-09-22T00:00:00Z