Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
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Genome-wide prediction and validation of peptides that bind human prosurvival Bcl-2 proteinsProto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosisNoxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cellsBcl-x(L) retrotranslocates Bax from the mitochondria into the cytosolRole of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cellsHuman Bop is a novel BH3-only member of the Bcl-2 protein familyPrevention of cytokine withdrawal-induced apoptosis by Mcl-1 requires interaction between Mcl-1 and BimInteraction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosisProapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.Heterodimerization of BAK and MCL-1 activated by detergent micellesDifferential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathwaysRole of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xLBimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosisThe vaccinia virus protein F1L interacts with Bim and inhibits activation of the pro-apoptotic protein BaxMcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell linesThe hepatitis C virus core protein contains a BH3 domain that regulates apoptosis through specific interaction with human Mcl-1PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cellsVaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligandsMutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosisIdentification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylationInhibition of mitochondrial neural cell death pathways by protein transduction of Bcl-2 family proteinsMutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenitePharmacological manipulation of cell death: clinical applications in sight?Endoplasmic reticulum stress: cell life and death decisions.Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosisThe Bcl-2 apoptotic switch in cancer development and therapyPUMA, a potent killer with or without p53Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivationSmall-molecule Bcl-2 antagonists as targeted therapy in oncologyProtein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosisThe BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cellsmir-29 regulates Mcl-1 protein expression and apoptosisBH3 mimetics to improve cancer therapy; mechanisms and examplesAn internal EELD domain facilitates mitochondrial targeting of Mcl-1 via a Tom70-dependent pathwayPuma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis inductionEvidence that membrane insertion of the cytosolic domain of Bcl-xL is governed by an electrostatic mechanismApoptotic pathways as a therapeutic target for colorectal cancer treatmentPotential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand?BH3 profiling--measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions
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P248
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P2860
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Differential targeting of pros ...... mplementary apoptotic function
@ast
Differential targeting of pros ...... mplementary apoptotic function
@en
Differential targeting of pros ...... mplementary apoptotic function
@en-gb
Differential targeting of pros ...... mplementary apoptotic function
@nl
type
label
Differential targeting of pros ...... mplementary apoptotic function
@ast
Differential targeting of pros ...... mplementary apoptotic function
@en
Differential targeting of pros ...... mplementary apoptotic function
@en-gb
Differential targeting of pros ...... mplementary apoptotic function
@nl
prefLabel
Differential targeting of pros ...... mplementary apoptotic function
@ast
Differential targeting of pros ...... mplementary apoptotic function
@en
Differential targeting of pros ...... mplementary apoptotic function
@en-gb
Differential targeting of pros ...... mplementary apoptotic function
@nl
P2093
P50
P921
P3181
P1433
P1476
Differential targeting of pros ...... mplementary apoptotic function
@en
P2093
Andrew Wei
Jamie I Fletcher
Mark G Hinds
Peter M Colman
Simon N Willis
P304
P3181
P356
10.1016/J.MOLCEL.2004.12.030
P407
P577
2005-02-01T00:00:00Z