Functional role of proline and tryptophan residues highly conserved among G protein-coupled receptors studied by mutational analysis of the m3 muscarinic receptor
about
Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptorsEvolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligandUnderstanding functional residues of the cannabinoid CB1.Role of the second extracellular loop of adenosine receptors in agonist and antagonist binding. Analysis of chimeric A1/A3 adenosine receptorsMolecular analysis of EMS-induced frizzled mutations in Drosophila melanogaster.A rhodopsin exhibiting binding ability to agonist all-trans-retinal.A proposed structure for transmembrane segment 7 of G protein-coupled receptors incorporating an asn-Pro/Asp-Pro motif.Two naturally occurring mutations in the type 1 melanin-concentrating hormone receptor abolish agonist-induced signaling.Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation.Structural basis of M3 muscarinic receptor dimer/oligomer formationMolecular Architecture of G Protein-Coupled Receptors.Dissecting the functions of conserved prolines within transmembrane helices of the D2 dopamine receptor.Functions of DPLIY motif and helix 8 of human melanocortin-3 receptor.New insights into human prostacyclin receptor structure and function through natural and synthetic mutations of transmembrane charged residues.Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels.Free backbone carbonyls mediate rhodopsin activationA constitutively active GPCR governs morphogenic transitions in Cryptococcus neoformansIdentification of specific transmembrane residues and ligand-induced interface changes involved in homo-dimer formation of a yeast G protein-coupled receptor.Alpha-helical, but not beta-sheet, propensity of proline is determined by peptide environment.Two amino acids, located in transmembrane domains VI and VII, determine the selectivity of the peptide agonist SMS 201-995 for the SSTR2 somatostatin receptorDIRECT-ID: An automated method to identify and quantify conformational variations--application to β2 -adrenergic GPCR.Mechanisms governing the activation and trafficking of yeast G protein-coupled receptors.Drug Binding Poses Relate Structure with Efficacy in the μ Opioid Receptor.A structural chemogenomics analysis of aminergic GPCRs: lessons for histamine receptor ligand design.The probable arrangement of the helices in G protein-coupled receptors.Roles of threonine 192 and asparagine 382 in agonist and antagonist interactions with M1 muscarinic receptors.Point mutations in bovine opsin can be classified in four groups with respect to their effect on the biosynthetic pathway of opsin.Ionization, partitioning, and dynamics of tryptophan octyl ester: implications for membrane-bound tryptophan residues.Effect of a toggle switch mutation in TM6 of the human adenosine A₃ receptor on Gi protein-dependent signalling and Gi-independent receptor internalization.By interacting with the C-terminal Phe of apelin, Phe255 and Trp259 in helix VI of the apelin receptor are critical for internalization.Molecular modeling of the M3 acetylcholine muscarinic receptor and its binding site.Conformational Change in the Ligand-Binding Pocket via a KISS1R Mutation (P147L) Leads to Isolated Gonadotropin-Releasing Hormone Deficiency.
P2860
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P2860
Functional role of proline and tryptophan residues highly conserved among G protein-coupled receptors studied by mutational analysis of the m3 muscarinic receptor
description
1993 nî lūn-bûn
@nan
1993 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Functional role of proline and ...... of the m3 muscarinic receptor
@ast
Functional role of proline and ...... of the m3 muscarinic receptor
@en
Functional role of proline and ...... of the m3 muscarinic receptor
@nl
type
label
Functional role of proline and ...... of the m3 muscarinic receptor
@ast
Functional role of proline and ...... of the m3 muscarinic receptor
@en
Functional role of proline and ...... of the m3 muscarinic receptor
@nl
prefLabel
Functional role of proline and ...... of the m3 muscarinic receptor
@ast
Functional role of proline and ...... of the m3 muscarinic receptor
@en
Functional role of proline and ...... of the m3 muscarinic receptor
@nl
P2093
P2860
P1433
P1476
Functional role of proline and ...... of the m3 muscarinic receptor
@en
P2093
P2860
P304
P356
10.1002/J.1460-2075.1993.TB05661.X
P407
P577
1993-01-01T00:00:00Z