Reactivation of developmentally silenced globin genes by forced chromatin looping. - Test2 - elhamkhani - TriplyDB

Reactivation of developmentally silenced globin genes by forced chromatin looping.

Reactivation of developmentally silenced globin genes by forced chromatin looping.

http://www.wikidata.org/entity/Q34052021

about

The Chromatin Signature of Pluripotency: Establishment and Maintenance The second decade of 3C technologies: detailed insights into nuclear organization Understanding Spatial Genome Organization: Methods and Insights Imaging Transcription: Past, Present, and Future Minor Loops in Major Folds: Enhancer-Promoter Looping, Chromatin Restructuring, and Their Association with Transcriptional Regulation and Disease Enabling functional genomics with genome engineering Genomic approaches to identifying targets for treating β hemoglobinopathies Getting the genome in shape: the formation of loops, domains and compartments Chromatin Dynamics in Lineage Commitment and Cellular Reprogramming Anemia: progress in molecular mechanisms and therapies The epigenome: the next substrate for engineering Many paths lead chromatin to the nuclear periphery Chromatin regulation at the frontier of synthetic biology β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters Bioinformatics and Drug Discovery.The transcription factor GATA1 regulates NBEAL2 expression through a long-distance enhancer.Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability Efficient chromosomal-scale DNA looping in Escherichia coli using multiple DNA-looping elements Systematic mapping of functional enhancer-promoter connections with CRISPR interference.Epigenetic characteristics of the mitotic chromosome in 1D and 3D.Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin.Genome-wide mapping and analysis of chromosome architecture.Insights from space: potential role of diet in the spatial organization of chromosomes.Enhancer-bound LDB1 regulates a corticotrope promoter-pausing repression program.ZNF300 knockdown inhibits forced megakaryocytic differentiation by phorbol and erythrocytic differentiation by arabinofuranosyl cytidine in K562 cells Chromosome Architecture and Genome Organization Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/γ-globin looping.Histone modifications rather than the novel regional centromeres of Zymoseptoria tritici distinguish core and accessory chromosomes Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding.Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease.Modulation of tissue repair by regeneration enhancer elements.Chromatin looping as a target for altering erythroid gene expression A genome editing primer for the hematologist Artificial zinc finger DNA binding domains: versatile tools for genome engineering and modulation of gene expression.Long-range looping of a locus control region drives tissue-specific chromatin packing within a multigene cluster Editing the epigenome: technologies for programmable transcription and epigenetic modulation.Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and β-thalassemia

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Reactivation of developmentally silenced globin genes by forced chromatin looping.

http://www.wikidata.org/entity/Q34052021

description

2014 nî lūn-bûn

@nan

2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի օգոստոսին հրատարակված գիտական հոդված

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2014年の論文

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年学术文章

@zh-my

2014年学术文章

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2014年學術文章

@yue

name

Reactivation of developmentally silenced globin genes by forced chromatin looping.

@ast

Reactivation of developmentally silenced globin genes by forced chromatin looping.

@en

Reactivation of developmentally silenced globin genes by forced chromatin looping.

@nl

type

label

Reactivation of developmentally silenced globin genes by forced chromatin looping.

@ast

Reactivation of developmentally silenced globin genes by forced chromatin looping.

@en

Reactivation of developmentally silenced globin genes by forced chromatin looping.

@nl

prefLabel

Reactivation of developmentally silenced globin genes by forced chromatin looping.

@ast

Reactivation of developmentally silenced globin genes by forced chromatin looping.

@en

Reactivation of developmentally silenced globin genes by forced chromatin looping.

@nl

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J.CELL.2014.05.050

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Reactivation of developmentally silenced globin genes by forced chromatin looping

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Andreas Reik

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Ann Dean

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Gerd A Blobel

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Jeremy W Rupon

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Kristen S Jahn

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Wulan Deng

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P2860

A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression

Looping and interaction between hypersensitive sites in the active beta-globin locus

Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor

Global regulation of erythroid gene expression by transcription factor GATA-1

RNA-guided gene activation by CRISPR-Cas9-based transcription factors

Developmental and species-divergent globin switching are driven by BCL11A

The active spatial organization of the beta-globin locus requires the transcription factor EKLF

SCL and associated proteins distinguish active from repressive GATA transcription factor complexes

Therapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patients

Induction of human gamma globin gene expression by histone deacetylase inhibitors

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