Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation
about
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activationDual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activitySupramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials.A highly efficient peptide substrate for EGFR activates the kinase by inducing aggregationPrion-like nanofibrils of small molecules (PriSM) selectively inhibit cancer cells by impeding cytoskeleton dynamicsUnraveling the mechanism of cell death induced by chemical fibrils.Small-molecule procaspase activators identified using fluorescence polarization.Turning on caspases with genetics and small moleculesEnzyme-instructed self-assembly: a multistep process for potential cancer therapyPost-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR.Derivatives of Procaspase-Activating Compound 1 (PAC-1) and their Anticancer Activities.Non-stoichiometric inhibition in integrated lead finding - a literature review.Differential effects of procaspase-3 activating compounds in the induction of cancer cell death.Fibrils colocalize caspase-3 with procaspase-3 to foster maturation.Enzyme-Instructed Intracellular Molecular Self-Assembly to Boost Activity of Cisplatin against Drug-Resistant Ovarian Cancer CellsInnovation in academic chemical screening: filling the gaps in chemical biologyImaging self-assembly dependent spatial distribution of small molecules in a cellular environment.Small molecules as pro-apoptotic anticancer agents.Nanoscale Assemblies of Small Molecules Control the Fate of CellsAmino Acids and Peptide-Based Supramolecular Hydrogels for Three-Dimensional Cell Culture.Colloidal aggregation causes inhibition of G protein-coupled receptors.Mixing biomimetic heterodimers of nucleopeptides to generate biocompatible and biostable supramolecular hydrogels.Probing nanoscale self-assembly of nonfluorescent small molecules inside live mammalian cells.Tandem aldehyde-alkyne-amine coupling/cycloisomerization: A new synthesis of coumarinsEnzyme transformation to modulate the ligand-receptor interactions between small molecules.Disruption of the dynamics of microtubules and selective inhibition of glioblastoma cells by nanofibers of small hydrophobic molecules.Prion-like nanofibrils of small molecules (PriSM): A new frontier at the intersection of supramolecular chemistry and cell biology.Ligand-receptor interaction catalyzes the aggregation of small molecules to induce cell necroptosis.Luminescent platinum(ii) complexes with self-assembly and anti-cancer properties: hydrogel, pH dependent emission color and sustained-release properties under physiological conditions.Enzyme-Instructed Assembly and Disassembly Processes for Targeting Downregulation in Cancer Cells.Phosphorylation at Ser8 as an Intrinsic Regulatory Switch to Regulate the Morphologies and Structures of Alzheimer's 40-residue β-Amyloid (Aβ40) Fibrils.Galactose-decorated light-responsive hydrogelator precursors for selectively killing cancer cells.Selectively Inducing Cancer Cell Death by Intracellular Enzyme-Instructed Self-Assembly (EISA) of Dipeptide Derivatives.
P2860
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P2860
Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation
description
2011 nî lūn-bûn
@nan
2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Self-assembling small molecule ...... aspase-3 to promote activation
@ast
Self-assembling small molecule ...... aspase-3 to promote activation
@en
Self-assembling small molecule ...... aspase-3 to promote activation
@nl
type
label
Self-assembling small molecule ...... aspase-3 to promote activation
@ast
Self-assembling small molecule ...... aspase-3 to promote activation
@en
Self-assembling small molecule ...... aspase-3 to promote activation
@nl
prefLabel
Self-assembling small molecule ...... aspase-3 to promote activation
@ast
Self-assembling small molecule ...... aspase-3 to promote activation
@en
Self-assembling small molecule ...... aspase-3 to promote activation
@nl
P2860
P356
P1476
Self-assembling small molecule ...... aspase-3 to promote activation
@en
P2093
James A Wells
Julie A Zorn
P2860
P304
19630-19633
P356
10.1021/JA208350U
P407
P577
2011-11-17T00:00:00Z