Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery.
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Discovery of FabH/FabF inhibitors from natural products.Biotin synthesis begins by hijacking the fatty acid synthetic pathwayDiscovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic propertiesA Review on Platensimycin: A Selective FabF InhibitorStructure and function of biotin-dependent carboxylasesGenetic resources for advanced biofuel production described with the Gene OntologyThe dynamic organization of fungal acetyl-CoA carboxylase.Structure of the human beta-ketoacyl [ACP] synthase from the mitochondrial type II fatty acid synthaseMalonyl-CoA: acyl carrier protein transacylase fromHelicobacter pylori: Crystal structure and its interaction with acyl carrier proteinType I and type II fatty acid biosynthesis in Eimeria tenella: enoyl reductase activity and structureStructural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ)Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylaseInhibition of the fungal fatty acid synthase type I multienzyme complexA class of selective antibacterials derived from a protein kinase inhibitor pharmacophoreSlow-Onset Inhibition of the FabI Enoyl Reductase from Francisella tularensis : Residence Time and in Vivo ActivityCrystal Structures of Mycobacterium tuberculosis KasA Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by ThiolactomycinCrystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzymeNew design platform for malonyl-CoA-acyl carrier protein transacylaseMode of Action, In Vitro Activity, and In Vivo Efficacy of AFN-1252, a Selective Antistaphylococcal FabI InhibitorStructural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteriaStructural Basis for Feed-Forward Transcriptional Regulation of Membrane Lipid Homeostasis in Staphylococcus aureusSelective inhibition of Biotin Protein Ligase from Staphylococcus aureusDiscovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosaCrystal Structure of Carboxyltransferase from Staphylococcus aureus Bound to the Antibacterial Agent Moiramide BResistance Mechanisms and the Future of Bacterial Enoyl-Acyl Carrier Protein Reductase (FabI) AntibioticsFapR: From Control of Membrane Lipid Homeostasis to a Biotechnological ToolUsing modern tools to probe the structure-function relationship of fatty acid synthasesEvolution of acyl-ACP-thioesterases and β-ketoacyl-ACP-synthases revealed by protein-protein interactionsVibrio cholerae FabV defines a new class of enoyl-acyl carrier protein reductaseHeterologous expression of mycobacterial proteins in Saccharomyces cerevisiae reveals two physiologically functional 3-hydroxyacyl-thioester dehydratases, HtdX and HtdY, in addition to HadABC and HtdZBiochemical and structural characterization of an essential acyl coenzyme A carboxylase from Mycobacterium tuberculosisFunction of heterologous Mycobacterium tuberculosis InhA, a type 2 fatty acid synthase enzyme involved in extending C20 fatty acids to C60-to-C90 mycolic acids, during de novo lipoic acid synthesis in Saccharomyces cerevisiaeMycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosisMechanism and inhibition of the FabV enoyl-ACP reductase from Burkholderia malleiFatty acid biosynthesis in Pseudomonas aeruginosa is initiated by the FabY class of β-ketoacyl acyl carrier protein synthasesDeletion of the β-acetoacetyl synthase FabY in Pseudomonas aeruginosa induces hypoacylation of lipopolysaccharide and increases antimicrobial susceptibilityFatty acid synthesis in Escherichia coli and its applications towards the production of fatty acid based biofuelsA rapid fluorometric assay for the S-malonyltransacylase FabD and other sulfhydryl utilizing enzymesIdentification of new compounds with high activity against stationary phase Borrelia burgdorferi from the NCI compound collectionMycobacterial phylogenomics: an enhanced method for gene turnover analysis reveals uneven levels of gene gain and loss among species and gene families
P2860
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P2860
Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery.
@ast
Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery.
@en
Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery.
@nl
type
label
Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery.
@ast
Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery.
@en
Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery.
@nl
prefLabel
Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery.
@ast
Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery.
@en
Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery.
@nl
P1476
Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery.
@en
P2093
Campbell JW
Cronan JE Jr
P304
P356
10.1146/ANNUREV.MICRO.55.1.305
P577
2001-01-01T00:00:00Z