Pathological alpha-synuclein propagates through neural networks
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Neurodegenerative diseases: expanding the prion conceptPropagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Parkinson's disease: animal models and dopaminergic cell vulnerabilityAlpha-synuclein spreading in Parkinson's diseaseWhole-brain 3D mapping of human neural transplant innervation.Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity.The Interplay between Alpha-Synuclein Clearance and SpreadingProgression of Seed-Induced Aβ Deposition within the Limbic ConnectomeChronic exposure to cerebrospinal fluid of multiple system atrophy in neuroblastoma and glioblastoma cells induces cytotoxicity via ER stress and autophagy activationHaploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregatesTransport of cargo from periphery to brain by circulating monocytes.Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein.Bent out of shape: α-Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease.Altered Expression Patterns of Inflammation-Associated and Trophic Molecules in Substantia Nigra and Striatum Brain Samples from Parkinson's Disease, Incidental Lewy Body Disease and Normal Control Cases.Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tauResting state in Parkinson's disease dementia and dementia with Lewy bodies: commonalities and differencesInduction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's diseaseReview: Novel treatment strategies targeting alpha-synuclein in multiple system atrophy as a model of synucleinopathyα-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule AssemblyThe evolutionary scope and neurological disease linkage of yeast-prion-like proteins in humans.Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril.Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice.Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils.Propagation of pathological α-synuclein in marmoset brain.Neuropathology of multiple system atrophy: new thoughts about pathogenesis.Prions and Protein Assemblies that Convey Biological Information in Health and Disease.Is Parkinson's disease truly a prion-like disorder? An appraisal of current evidence.Alpha-synuclein propagation: New insights from animal models.The cellular prion protein (PrPC) as neuronal receptor for α-synuclein.Sorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology.Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein.Synaptic failure and α-synuclein.Targeting α-synuclein: Therapeutic options.The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation.How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases.Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43.Multiple system atrophy: pathogenic mechanisms and biomarkers.α-Synuclein: Experimental Pathology.Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers.
P2860
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P2860
Pathological alpha-synuclein propagates through neural networks
description
2014 nî lūn-bûn
@nan
2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Pathological alpha-synuclein propagates through neural networks
@ast
Pathological alpha-synuclein propagates through neural networks
@en
Pathological alpha-synuclein propagates through neural networks
@nl
type
label
Pathological alpha-synuclein propagates through neural networks
@ast
Pathological alpha-synuclein propagates through neural networks
@en
Pathological alpha-synuclein propagates through neural networks
@nl
prefLabel
Pathological alpha-synuclein propagates through neural networks
@ast
Pathological alpha-synuclein propagates through neural networks
@en
Pathological alpha-synuclein propagates through neural networks
@nl
P2093
P2860
P1476
Pathological alpha-synuclein propagates through neural networks
@en
P2093
Aki Shimozawa
Haruhiko Akiyama
Masami Masuda-Suzukake
Masato Hasegawa
P2860
P2888
P356
10.1186/S40478-014-0088-8
P577
2014-08-06T00:00:00Z
P6179
1009988456