Frameshift mutations in a single novel virulence factor alter the in vivo pathogenicity of Chlamydia trachomatis for the female murine genital tract.
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A path forward for the chlamydial virulence factor CPAFInnate immunity is sufficient for the clearance ofChlamydia trachomatisfrom the female mouse genital tractInfectivity of urogenital Chlamydia trachomatis plasmid-deficient, CT135-null, and double-deficient strains in female miceEarly microRNA expression profile as a prognostic biomarker for the development of pelvic inflammatory disease in a mouse model of chlamydial genital infection.Chlamydia trachomatis polymorphic membrane protein D is a virulence factor involved in early host-cell interactions.Benzylidene acylhydrazides inhibit chlamydial growth in a type III secretion- and iron chelation-independent manner.Plasmid-cured Chlamydia caviae activates TLR2-dependent signaling and retains virulence in the guinea pig model of genital tract infection.Infectivity acts as in vivo selection for maintenance of the chlamydial cryptic plasmidVaccination against Chlamydia genital infection utilizing the murine C. muridarum model.Murine Chlamydia trachomatis genital infection is unaltered by depletion of CD4+ T cells and diminished adaptive immunity.Culture-independent sequence analysis of Chlamydia trachomatis in urogenital specimens identifies regions of recombination and in-patient sequence mutations.Generation of targeted Chlamydia trachomatis null mutants.In vitro passage selects for Chlamydia muridarum with enhanced infectivity in cultured cells but attenuated pathogenicity in mouse upper genital tract.A live-attenuated chlamydial vaccine protects against trachoma in nonhuman primates.Genomic variant representation in a Chlamydia population is dynamic and adaptive with dependence on in vitro and in vivo passage.Chlamydia psittaci genetic variants differ in virulence by modulation of host immunityIntrauterine infection with plasmid-free Chlamydia muridarum reveals a critical role of the plasmid in chlamydial ascension and establishes a model for evaluating plasmid-independent pathogenicity.Effect of inflammatory response on in vivo competition between two chlamydial variants in the guinea pig model of inclusion conjunctivitis.Chlamydia trachomatis In Vivo to In Vitro Transition Reveals Mechanisms of Phase Variation and Down-Regulation of Virulence FactorsMutational Analysis of the Chlamydia muridarum Plasticity ZoneChlamydial variants differ in ability to ascend the genital tract in the guinea pig model of chlamydial genital infection.In Vivo and Ex Vivo Imaging Reveals a Long-Lasting Chlamydial Infection in the Mouse Gastrointestinal Tract following Genital Tract InoculationThe Chlamydia muridarum Organisms Fail to Auto-Inoculate the Mouse Genital Tract after Colonization in the Gastrointestinal Tract for 70 days.Development of a pigtail macaque model of sexually transmitted infection/HIV coinfection using Chlamydia trachomatis, Trichomonas vaginalis, and SHIV(SF162P3)A Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production.Genomic stability of genotyping markers in Chlamydia trachomatisExpression and localization of predicted inclusion membrane proteins in Chlamydia trachomatisPopulation genomics of Chlamydia trachomatis: insights on drift, selection, recombination, and population structure.The Chromosome-Encoded Hypothetical Protein TC0668 Is an Upper Genital Tract Pathogenicity Factor of Chlamydia muridarum.Differences in infectivity and induction of infertility: a comparative study of Chlamydia trachomatis strains in the murine modelChlamydia trachomatis virulence factor CT135 is stable in vivo but highly polymorphic in vitro.TLR2, TLR4 and TLR9 genotypes and haplotypes in the susceptibility to and clinical course of Chlamydia trachomatis infections in Dutch women.CD4+ T cells are necessary and sufficient to confer protection against Chlamydia trachomatis infection in the murine upper genital tract.Animal models for studying female genital tract infection with Chlamydia trachomatisThe Chlamydia-Secreted Protease CPAF Promotes Chlamydial Survival in the Mouse Lower Genital TractMicroRNAs Modulate Pathogenesis Resulting from Chlamydial Infection in MiceComparison of Murine Cervicovaginal Infection by Chlamydial Strains: Identification of Extrusions Shed In vivoReduced live organism recovery and lack of hydrosalpinx in mice infected with plasmid-free Chlamydia muridarum.Infection of Hysterectomized Mice with Chlamydia muridarum and Chlamydia trachomatis.Chlamydia trachomatis ChxR is a transcriptional regulator of virulence factors that function in in vivo host-pathogen interactions.
P2860
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P2860
Frameshift mutations in a single novel virulence factor alter the in vivo pathogenicity of Chlamydia trachomatis for the female murine genital tract.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Frameshift mutations in a sing ...... e female murine genital tract.
@ast
Frameshift mutations in a sing ...... e female murine genital tract.
@en
Frameshift mutations in a sing ...... e female murine genital tract.
@nl
type
label
Frameshift mutations in a sing ...... e female murine genital tract.
@ast
Frameshift mutations in a sing ...... e female murine genital tract.
@en
Frameshift mutations in a sing ...... e female murine genital tract.
@nl
prefLabel
Frameshift mutations in a sing ...... e female murine genital tract.
@ast
Frameshift mutations in a sing ...... e female murine genital tract.
@en
Frameshift mutations in a sing ...... e female murine genital tract.
@nl
P2093
P2860
P356
P1476
Frameshift mutations in a sing ...... e female murine genital tract.
@en
P2093
Craig Martens
Donald J Gardner
Elizabeth M Selleck
Gail L Sturdevant
Harlan D Caldwell
John H Carlson
Laszlo Kari
Linnell B Randall
Morgan M Goheen
Norma Olivares-Zavaleta
P2860
P304
P356
10.1128/IAI.00386-10
P407
P577
2010-06-14T00:00:00Z