Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics.
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The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolutionBiosynthesis of oxygen and nitrogen-containing heterocycles in polyketidesLessons from the past and charting the future of marine natural products drug discovery and chemical biologyOmuralide and vibralactone: differences in the proteasome- β-lactone-γ-lactam binding scaffold alter target preferencesMarine sediment-derived Streptomyces bacteria from British Columbia, Canada are a promising microbiota resource for the discovery of antimicrobial natural productsAntileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor salinosporamide A (Marizomib).An L-threonine transaldolase is required for L-threo-β-hydroxy-α-amino acid assembly during obafluorin biosynthesisInsights from the sea: structural biology of marine polyketide synthasesGlutamate decarboxylase-dependent acid resistance in orally acquired bacteria: function, distribution and biomedical implications of the gadBC operon.The marine actinomycete genus Salinispora: a model organism for secondary metabolite discoveryStructure and activity of lobophorins from a turrid mollusk-associated Streptomyces spDiversity and biotechnological potential of microorganisms associated with marine sponges.Targeted capture and heterologous expression of the Pseudoalteromonas alterochromide gene cluster in Escherichia coli represents a promising natural product exploratory platform.Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation.Total synthesis and absolute stereochemistry of the proteasome inhibitors cystargolides A and B.Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome MiningExploiting nature's rich source of proteasome inhibitors as starting points in drug development.Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity.The generation of "unnatural" products: synthetic biology meets synthetic chemistry.Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome systemDiscovering new bioactive molecules from microbial sources.Discovery and assembly-line biosynthesis of the lymphostin pyrroloquinoline alkaloid family of mTOR inhibitors in Salinispora bacteria.Sioxanthin, a novel glycosylated carotenoid, reveals an unusual subclustered biosynthetic pathway.Diastereoselective synthesis of γ- and δ-lactams from imines and sulfone-substituted anhydrides.Minimization of the Thiolactomycin Biosynthetic Pathway Reveals that the Cytochrome P450 Enzyme TlmF Is Required for Five-Membered Thiolactone Ring Formation.Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse.Bluegenics: Bioactive Natural Products of Medicinal Relevance and Approaches to Their Diversification.Biocatalysis at Work: Applications in the Development of Sagopilone.Bacterial self-resistance to the natural proteasome inhibitor salinosporamide A.Molecular mechanisms of acquired proteasome inhibitor resistance.The carmaphycins: new proteasome inhibitors exhibiting an α,β-epoxyketone warhead from a marine cyanobacterium.Mining the cinnabaramide biosynthetic pathway to generate novel proteasome inhibitors.Coupled Biosynthesis of Volatiles and Salinosporamide A in Salinispora tropica.Function-related replacement of bacterial siderophore pathways.Selective growth inhibition of human malignant melanoma cells by syringic acid-derived proteasome inhibitors.Phylogenetic appraisal of antagonistic, slow growing actinomycetes isolated from hypersaline inland solar salterns at Sambhar salt Lake, India.New natural products identified by combined genomics-metabolomics profiling of marine Streptomyces sp. MP131-18.Bioactivity-guided genome mining reveals the lomaiviticin biosynthetic gene cluster in Salinispora tropicaBiosynthesis of ebelactone A: isotopic tracer, advanced precursor and genetic studies reveal a thioesterase-independent cyclization to give a polyketide β-lactone.Direct catalytic asymmetric synthesis of N-heterocycles from commodity acid chlorides by employing α,β-unsaturated acylammonium salts.
P2860
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P2860
Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics.
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Salinosporamide natural produc ...... sing cancer chemotherapeutics.
@ast
Salinosporamide natural produc ...... sing cancer chemotherapeutics.
@en
Salinosporamide natural produc ...... sing cancer chemotherapeutics.
@nl
type
label
Salinosporamide natural produc ...... sing cancer chemotherapeutics.
@ast
Salinosporamide natural produc ...... sing cancer chemotherapeutics.
@en
Salinosporamide natural produc ...... sing cancer chemotherapeutics.
@nl
prefLabel
Salinosporamide natural produc ...... sing cancer chemotherapeutics.
@ast
Salinosporamide natural produc ...... sing cancer chemotherapeutics.
@en
Salinosporamide natural produc ...... sing cancer chemotherapeutics.
@nl
P2860
P356
P1476
Salinosporamide natural produc ...... ising cancer chemotherapeutics
@en
P2093
Bradley S Moore
P2860
P304
P356
10.1002/ANIE.201000728
P407
P577
2010-12-01T00:00:00Z