Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system
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UBA1: At the Crossroads of Ubiquitin Homeostasis and NeurodegenerationTargeting the ubiquitin pathway for cancer treatmentStructure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar AffinitiesAn Inducible System for Rapid Degradation of Specific Cellular Proteins Using Proteasome AdaptorsDrug Discovery Targeting Bromodomain-Containing Protein 4.The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solutionTargeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation.Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.Catalytic in vivo protein knockdown by small-molecule PROTACs.Induced protein degradation: an emerging drug discovery paradigm.Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic TaggingProtein degradation: Prime time for PROTACs.A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic DefectsCovalent Tethering of Fragments For Covalent Probe DiscoveryChemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathwayA Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic MechanismOn-Demand Targeting: Investigating Biology with Proximity-Directed Chemistry.Degradation of Akt using protein-catalyzed capture agents.A Novel Destabilizing Domain Based on a Small-Molecule Dependent FluorophoreSmall-molecule control of protein function through Staudinger reduction.SCF ubiquitin ligase-targeted therapies.Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay.Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway.Boc3Arg-Linked Ligands Induce Degradation by Localizing Target Proteins to the 20S Proteasome.Blocking protein quality control to counter hereditary cancers.Small Molecule Modulators of RING-Type E3 Ligases: MDM and Cullin Families as Targets.Degradation of HaloTag-fused nuclear proteins using bestatin-HaloTag ligand hybrid molecules.Machine Learning To Predict Cell-Penetrating Peptides for Antisense Delivery.
P2860
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P2860
Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system
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article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Small-molecule control of intr ...... he ubiquitin proteasome system
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type
label
Small-molecule control of intr ...... he ubiquitin proteasome system
@en
prefLabel
Small-molecule control of intr ...... he ubiquitin proteasome system
@en
P2860
P356
P1476
Small-molecule control of intr ...... he ubiquitin proteasome system
@en
P2093
Craig M Crews
Dennis L Buckley
P2860
P304
P356
10.1002/ANIE.201307761
P407
P577
2014-01-23T00:00:00Z