Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine.
about
Stoichiometry of human recombinant neuronal nicotinic receptors containing the b3 subunit expressed in Xenopus oocytesFormation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approachThe impact of human hyperekplexia mutations on glycine receptor structure and functionFunctional studies cast light on receptor statesAllosteric activation mechanism of the cys-loop receptorsMapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete modelPoint mutation in the first transmembrane region of the beta 2 subunit of the gamma--aminobutyric acid type A receptor alters desensitization kinetics of gamma--aminobutyric acid- and anesthetic-induced channel gatingA single beta subunit M2 domain residue controls the picrotoxin sensitivity of alphabeta heteromeric glycine receptor chloride channels.Estimation of ligand affinity constants for receptor states in functional studies involving the allosteric modulation of G protein-coupled receptors: implications for ligand bias.ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.Conserved allosteric hot spots in the transmembrane domains of cystic fibrosis transmembrane conductance regulator (CFTR) channels and multidrug resistance protein (MRP) pumps.Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol.Structural model for gamma-aminobutyric acid receptor noncompetitive antagonist binding: widely diverse structures fit the same siteFlapping loops: roles for hinges in a ligand-binding domain of the nicotinic receptor.Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.Energetic contributions to channel gating of residues in the muscle nicotinic receptor β1 subunit.Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol.Key roles of hydrophobic rings of TM2 in gating of the alpha9alpha10 nicotinic cholinergic receptorBenzodiazepine modulation of partial agonist efficacy and spontaneously active GABA(A) receptors supports an allosteric model of modulation.Mechanism of action of benzodiazepines on GABAA receptors.Use of concatemers of ligand-gated ion channel subunits to study mechanisms of steroid potentiation.An allosteric coagonist model for propofol effects on α1β2γ2L γ-aminobutyric acid type A receptors.The atypical cation-conduction and gating properties of ELIC underscore the marked functional versatility of the pentameric ligand-gated ion-channel fold.Mutations in the GABAA receptor that mimic the allosteric ligand etomidate.Two etomidate sites in α1β2γ2 γ-aminobutyric acid type A receptors contribute equally and noncooperatively to modulation of channel gating.Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors.Incomplete incorporation of tandem subunits in recombinant neuronal nicotinic receptors.alpha1beta2delta, a silent GABAA receptor: recruitment by tracazolate and neurosteroids.Subunit stoichiometry and arrangement in a heteromeric glutamate-gated chloride channel.Long-range coupling between the extracellular gates and the intracellular ATP binding domains of multidrug resistance protein pumps and cystic fibrosis transmembrane conductance regulator channelsNovel missense mutations in the glycine receptor β subunit gene (GLRB) in startle diseaseState-dependent etomidate occupancy of its allosteric agonist sites measured in a cysteine-substituted GABAA receptor.Converting nonhydrolyzable nucleotides to strong cystic fibrosis transmembrane conductance regulator (CFTR) agonists by gain of function (GOF) mutationsTryptophan mutations at azi-etomidate photo-incorporation sites on alpha1 or beta2 subunits enhance GABAA receptor gating and reduce etomidate modulation.Competitive antagonists facilitate the recovery from desensitization of α1β2γ2 GABAA receptors expressed in Xenopus oocytesAn engineered glutamate-gated chloride (GluCl) channel for sensitive, consistent neuronal silencing by ivermectin.A unified view of cystic fibrosis transmembrane conductance regulator (CFTR) gating: combining the allosterism of a ligand-gated channel with the enzymatic activity of an ATP-binding cassette (ABC) transporterMonod-Wyman-Changeux allosteric mechanisms of action and the pharmacology of etomidate.The structural mechanism of the Cys-loop receptor desensitization.The actions of drug combinations on the GABAA receptor manifest as curvilinear isoboles of additivity.
P2860
Q24650978-F249D998-AAB2-470E-9ED6-486A8C6F1148Q24673473-002AC0B6-90D6-4642-8C9B-D554ACEFBA77Q26830661-18C307F2-B61E-499B-9A5C-C0ECD48A734DQ28083760-D41F7215-80DE-4568-B57E-16E437579439Q28245066-F1C11DAE-04C0-4DD1-ABFE-91B836632981Q28293890-A9998E73-BB2E-4DEC-900A-EB38F6FF1DD1Q28582911-3032DC75-D0AE-43BC-BBC3-7E3990A4DA11Q31962028-7350E854-EE82-4A0D-A1B8-42A4E598729EQ33638068-E3635022-7853-44B9-8FA3-24AF1EB785BCQ33734745-FDB40CC4-1174-415A-BC76-5A30BD0F0BD8Q33931117-BF39D188-D93F-4E50-AA88-13C2D11F1F9EQ34511713-0EB19E6E-E688-4DB0-A48F-5A20CA60137FQ34597062-73236AE3-1F5B-4170-AACF-533CB1CC971DQ34701023-38AC7348-39C7-466B-92ED-F979F4A2ED6BQ35024917-CF468DE3-0691-4AC8-81B9-5E9C364C6084Q35032615-8EF7CBCD-48C2-4BF6-9D44-ADA703812963Q35042675-B42CF952-2B05-4B05-911A-F17142B3AECDQ35049025-3AA02870-B80C-45A4-8EE9-68C2CE391569Q35049035-BFD03CDB-3F54-4F77-86FA-629076E0225AQ35546302-B4C33A01-A780-4F0E-A3EF-C3D25B2872D5Q35581094-C6F98CC5-7455-4798-BEB9-6687E8DABB2DQ35682320-05C52CBD-AA57-4E02-80D7-EC83BCF2B05DQ35795776-DA4714C8-F780-484B-A890-250E47FC0311Q35988566-014F211A-76D1-4450-82A2-613A1CB6C684Q36005514-62B9908E-D3A4-4FCE-99D8-EF67A5E56550Q36077758-A4F3ECEA-EDD6-4322-8050-4AA17E79ADF1Q36447363-B684466B-C991-44D1-B763-D4D4107F934CQ36495131-6097F658-885B-4285-AACA-0CE720956827Q36563443-ED96A465-801D-4ECA-BEE6-2FF93D6827D4Q36570921-150528DF-CBC4-4189-A437-2EA9167320B7Q36636926-1AD236E1-5ACB-4ECB-9CAE-48B13C9E24DEQ36852531-8BC6716A-BE33-4337-8E48-BF79E52B5429Q36928934-C4A24B56-5C8A-4778-9F9C-61B86E49C468Q37000978-86F7CD4A-0884-437A-A4CF-6BEA49FDE8DAQ37151606-5906A2C5-4CF0-417F-904B-1C1E7E7601EEQ37175116-7DAEA7EF-D959-4788-99DA-124C7F69E4F3Q37836188-8E5D08A0-C856-489A-9768-8CC713F7B4AAQ38011975-555E3C79-D744-4E86-B5E5-65B704220F15Q38080450-433119FF-5B6D-4080-BDC8-3F1DE70074D0Q38633275-AD466E5D-AE3C-4547-8AEE-B4797FCCC546
P2860
Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine.
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Allosteric activation mechanis ...... n of the conserved M2 leucine.
@ast
Allosteric activation mechanis ...... n of the conserved M2 leucine.
@en
Allosteric activation mechanis ...... n of the conserved M2 leucine.
@nl
type
label
Allosteric activation mechanis ...... n of the conserved M2 leucine.
@ast
Allosteric activation mechanis ...... n of the conserved M2 leucine.
@en
Allosteric activation mechanis ...... n of the conserved M2 leucine.
@nl
prefLabel
Allosteric activation mechanis ...... n of the conserved M2 leucine.
@ast
Allosteric activation mechanis ...... n of the conserved M2 leucine.
@en
Allosteric activation mechanis ...... n of the conserved M2 leucine.
@nl
P2860
P1433
P1476
Allosteric activation mechanis ...... n of the conserved M2 leucine.
@en
P2093
P2860
P304
P356
10.1016/S0006-3495(99)77089-X
P407
P577
1999-11-01T00:00:00Z