Mechanism of action of benzodiazepines on GABAA receptors. - Test2 - elhamkhani - TriplyDB

Mechanism of action of benzodiazepines on GABAA receptors.

Mechanism of action of benzodiazepines on GABAA receptors.

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A unified model of the GABA(A) receptor comprising agonist and benzodiazepine binding sites GABA(A) receptors implicated in REM sleep control express a benzodiazepine binding site Abuse and dependence liability of benzodiazepine-type drugs: GABA(A) receptor modulation and beyond α2-containing GABA(A) receptors: a requirement for midazolam-escalated aggression and social approach in mice LY293558 prevents soman-induced pathophysiological alterations in the basolateral amygdala and the development of anxiety.The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302.An epilepsy-related region in the GABA(A) receptor mediates long-distance effects on GABA and benzodiazepine binding sites.Hooked on benzodiazepines: GABAA receptor subtypes and addiction.A nonequilibrium binary elements-based kinetic model for benzodiazepine regulation of GABAA receptors.Behavioral effects of ethanol in cerebellum are age dependent: potential system and molecular mechanisms Effects of Serotonin on the Induction of Long-term Depression in the Rat Visual Cortex.Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor.Disulphide trapping of the GABA(A) receptor reveals the importance of the coupling interface in the action of benzodiazepines.Membrane potential measurements of isolated neurons using a voltage-sensitive dye A Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude)Different residues in the GABAA receptor benzodiazepine binding pocket mediate benzodiazepine efficacy and binding.Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations.Use of benzodiazepines and detoxification with methadone.Structural link between γ-aminobutyric acid type A (GABAA) receptor agonist binding site and inner β-sheet governs channel activation and allosteric drug modulation Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity.Desformylflustrabromine Modulates α4β2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the β2 Subunit From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors.Polydrug abuse: a review of opioid and benzodiazepine combination use Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents.alpha1beta2delta, a silent GABAA receptor: recruitment by tracazolate and neurosteroids.Estimating the efficiency of benzodiazepines on GABA(A) receptors comprising gamma1 or gamma2 subunits.Tandem couture: Cys-loop receptor concatamer insights and caveats.Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA.Potential network mechanisms mediating electroencephalographic beta rhythm changes during propofol-induced paradoxical excitation.Number and locations of agonist binding sites required to activate homomeric Cys-loop receptors The benzodiazepine diazepam potentiates responses of α1β2γ2L γ-aminobutyric acid type A receptors activated by either γ-aminobutyric acid or allosteric agonists.Clinical practice: the treatment of acute convulsive seizures in children.Impact of synaptic neurotransmitter concentration time course on the kinetics and pharmacological modulation of inhibitory synaptic currents.Psychotropic drugs and their impact on the treatment of paediatric dental patients.First line management of prolonged convulsive seizures in children and adults: good practice points.GABA transient sets the susceptibility of mIPSCs to modulation by benzodiazepine receptor agonists in rat hippocampal neurons.Intravenous and Intramuscular Formulations of Antiseizure Drugs in the Treatment of Epilepsy.Mechanism of Allosteric Modulation of the Cys-loop Receptors.Determining the relative efficacy of positive allosteric modulators of the GABAA receptor: design of a screening approach.The F-loop of the GABA A receptor gamma2 subunit contributes to benzodiazepine modulation.

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P2860

Mechanism of action of benzodiazepines on GABAA receptors.

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2006年の論文

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2006年论文

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Mechanism of action of benzodiazepines on GABAA receptors.

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Mechanism of action of benzodiazepines on GABAA receptors.

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Mechanism of action of benzodiazepines on GABAA receptors.

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Mechanism of action of benzodiazepines on GABAA receptors.

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Mechanism of action of benzodiazepines on GABAA receptors.

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British Journal of Pharmacology

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Mechanism of action of benzodiazepines on GABAA receptors.

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Claudia Campo-Soria

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David S Weiss

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Yongchang Chang

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P2860

Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons

Structure and gating mechanism of the acetylcholine receptor pore

Differential regulation of gamma-aminobutyric acid receptor channels by diazepam and phenobarbital

A single histidine in GABAA receptors is essential for benzodiazepine agonist binding

Intrinsic dynamics of an enzyme underlies catalysis

Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine.

Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABA(A) receptors supports an allosteric model of modulation.

gamma-Aminobutyric acid type A receptor point mutation increases the affinity of compounds for the benzodiazepine site.

Evidence for involvement of GABA in the action of benzodiazepines: studies on rat cerebellum.

Possible involvement of GABA in the central actions of benzodiazepines.

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984-990

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10.1038/SJ.BJP.0706796

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7

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148

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1751932

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