about
Rapamycin and its analogues (rapalogs) for tuberous sclerosis complexDistinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.Amino acids as regulators of gene expressionBiochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activitySpatial regulation of the mTORC1 system in amino acids sensing pathwayThe mTOR signalling pathway in human cancermTOR signaling: at the crossroads of plasticity, memory and diseasePEComas: the past, the present and the futureRheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signalingBalancing Akt with S6K: implications for both metabolic diseases and tumorigenesisIdentification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size controlRole of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathwaysRapamycin and rapalogs for tuberous sclerosis complexSystemic and nonrenal adverse effects occurring in renal transplant patients treated with mTOR inhibitorsRecent treatment advances and novel therapeutic approaches in epilepsyFinding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic targetSpatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatmentmTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and agingBeyond indigestion: emerging roles for lysosome-based signaling in human diseaseIκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathwaymTOR and cancer therapyAssociation of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growthE3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survivalEstrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of platelet-derived growth factor receptor-beta and ERK-1/2The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsyEpileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytesHereditary genodermatoses with cancer predispositionImpaired astrocytic gap junction coupling and potassium buffering in a mouse model of tuberous sclerosis complex.Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex.Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex.Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficitsp27Kip1 localization depends on the tumor suppressor protein tuberin.PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.Activation of extracellular regulated kinase and mechanistic target of rapamycin pathway in focal cortical dysplasia.Developing Antiepileptogenic Drugs for Acquired Epilepsy: Targeting the Mammalian Target of Rapamycin (mTOR) Pathway.Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells.
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Tuberous sclerosis: from tubers to mTOR.
@ast
Tuberous sclerosis: from tubers to mTOR.
@en
Tuberous sclerosis: from tubers to mTOR.
@nl
type
label
Tuberous sclerosis: from tubers to mTOR.
@ast
Tuberous sclerosis: from tubers to mTOR.
@en
Tuberous sclerosis: from tubers to mTOR.
@nl
prefLabel
Tuberous sclerosis: from tubers to mTOR.
@ast
Tuberous sclerosis: from tubers to mTOR.
@en
Tuberous sclerosis: from tubers to mTOR.
@nl
P2860
P1476
Tuberous sclerosis: from tubers to mTOR.
@en
P2093
Kwiatkowski DJ
P2860
P356
10.1046/J.1469-1809.2003.00012.X
P407
P577
2003-01-01T00:00:00Z