Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
about
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2Structural analysis and functional implications of the negative mTORC1 regulator REDD1Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycinmTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4EIdentification of Protor as a novel Rictor-binding component of mTOR complex-2Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitiveNutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagyA positive role of mammalian Tip41-like protein, TIPRL, in the amino-acid dependent mTORC1-signaling pathway through interaction with PP2AThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complexUpregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemiamTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signalingPRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.Signaling by target of rapamycin proteins in cell growth controlNutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylationThe C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylationAmino acids as regulators of gene expressionDisruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell developmentmTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cellsUpdates of mTOR inhibitorsResveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTORSpatial regulation of the mTORC1 system in amino acids sensing pathwayOsmotic stress regulates mammalian target of rapamycin (mTOR) complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor protein phosphorylationTargeting mTOR for the treatment of AML. New agents and new directionsThe mTOR signalling pathway in human cancerAn emerging role for TOR signaling in mammalian tissue and stem cell physiologyAkt and autophagy cooperate to promote survival of drug-resistant gliomaTargeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapymTOR: from growth signal integration to cancer, diabetes and ageingmTOR signaling in growth control and diseaseThe proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1Rapamycin and mTOR kinase inhibitorsCharacterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylationmTOR regulates memory CD8 T-cell differentiationIdentification of Sin1 as an essential TORC2 component required for complex formation and kinase activityThe Arabidopsis Mei2 homologue AML1 binds AtRaptor1B, the plant homologue of a major regulator of eukaryotic cell growthThe Arabidopsis AtRaptor genes are essential for post-embryonic plant growth
P2860
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P248
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P2860
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
description
2002 nî lūn-bûn
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2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
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2002年の論文
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2002年学术文章
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2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
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name
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
@ast
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
@en
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
@en-gb
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
@nl
type
label
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
@ast
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
@en
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
@en-gb
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
@nl
prefLabel
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
@ast
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
@en
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
@en-gb
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
@nl
P2093
P921
P3181
P1433
P1476
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
@en
P2093
Chiharu Tokunaga
Joseph Avruch
Kazuyoshi Yonezawa
Ken-ichi Yoshino
Noriko Oshiro
Sujuti Hidayat
Xiaomeng Long
Yoshiko Maruki
P304
P3181
P356
10.1016/S0092-8674(02)00833-4
P407
P50
P577
2002-07-26T00:00:00Z