Telomere loss as a mechanism for chromosome instability in human cancer
about
Telomere dysfunction and chromosome instabilityMolecular regulation of telomerase activity in agingRoles of the PI3K/Akt pathway in Epstein-Barr virus-induced cancers and therapeutic implicationsThe pursuit of oncotargets through understanding defective cell regulation3D imaging of telomeres and nuclear architecture: An emerging tool of 3D nano-morphology-based diagnosis.Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencingExpression of telomere binding proteins in gastric cancer and correlation with clinicopathological parameters.A novel checkpoint and RPA inhibitory pathway regulated by Rif1The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers.New therapeutic targets in soft tissue sarcoma.The presence of telomere fusion in sporadic colon cancer independently of disease stage, TP53/KRAS mutation status, mean telomere length, and telomerase activityThe role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line.Subtelomeric regions in mammalian cells are deficient in DNA double-strand break repair.Increased telomere length and proliferative potential in peripheral blood mononuclear cells of adults of different ages stimulated with concanavalin A.Using passenger mutations to estimate the timing of driver mutations and identify mutator alterationsThe replicometer is broken: telomeres activate cellular senescence in response to genotoxic stresses.Genetics of leukocyte telomere length and its role in atherosclerosis.PIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells.Stn1 is critical for telomere maintenance and long-term viability of somatic human cells.Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications.Genome-wide profiles of H2AX and γ-H2AX differentiate endogenous and exogenous DNA damage hotspots in human cells.ATM Inhibition Potentiates Death of Androgen Receptor-inactivated Prostate Cancer Cells with Telomere Dysfunction.Mechanisms of telomere loss and their consequences for chromosome instability.Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks.Cold-inducible RNA-binding protein CIRP/hnRNP A18 regulates telomerase activity in a temperature-dependent manner.Common variations in TERT-CLPTM1L locus are reproducibly associated with the risk of nasopharyngeal carcinoma in Chinese populationsNon-erythroid alpha spectrin prevents telomere dysfunction after DNA interstrand cross-link damageSister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4.Induction of Chromosomal Instability via Telomere Dysfunction and Epigenetic Alterations in Myeloid NeoplasiaLeukocyte telomere length in relation to the risk of Barrett's esophagus and esophageal adenocarcinomaAlternative lengthening of telomeres: recurrent cytogenetic aberrations and chromosome stability under extreme telomere dysfunction.Drug therapy of cancer.Human telomerase expression regulation.Chromosomal aberrations involving telomeres and interstitial telomeric sequences.Pharmaceutical regulation of telomerase and its clinical potentialTelomere dysfunction and its role in haematological cancer.The role of dicentric chromosome formation and secondary centromere deletion in the evolution of myeloid malignancy.Genomic instability: Crossing pathways at the origin of structural and numerical chromosome changes.Telomerase inhibitors: a patent review (2010-2015).Structural and functional association of androgen receptor with telomeres in prostate cancer cells.
P2860
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P2860
Telomere loss as a mechanism for chromosome instability in human cancer
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Telomere loss as a mechanism for chromosome instability in human cancer
@ast
Telomere loss as a mechanism for chromosome instability in human cancer
@en
Telomere loss as a mechanism for chromosome instability in human cancer
@nl
type
label
Telomere loss as a mechanism for chromosome instability in human cancer
@ast
Telomere loss as a mechanism for chromosome instability in human cancer
@en
Telomere loss as a mechanism for chromosome instability in human cancer
@nl
prefLabel
Telomere loss as a mechanism for chromosome instability in human cancer
@ast
Telomere loss as a mechanism for chromosome instability in human cancer
@en
Telomere loss as a mechanism for chromosome instability in human cancer
@nl
P2860
P1433
P1476
Telomere loss as a mechanism for chromosome instability in human cancer
@en
P2093
John P Murnane
P2860
P304
P356
10.1158/0008-5472.CAN-09-4357
P407
P577
2010-05-18T00:00:00Z