Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors.
about
When the genome plays dice: circumvention of the spindle assembly checkpoint and near-random chromosome segregation in multipolar cancer cell mitosesMassive genomic rearrangement acquired in a single catastrophic event during cancer developmentTelomere dysfunction and chromosome instabilityCentrosomal abnormalities, multipolar mitoses, and chromosomal instability in head and neck tumours with dysfunctional telomeresNew trends in molecular and cellular biomarker discovery for colorectal cancerModeling human endothelial cell transformation in vascular neoplasiasTherapeutic targeting of replicative immortalityVariation at the TERT locus and predisposition for cancerElevated tolerance to aneuploidy in cancer cells: estimating the fitness effects of chromosome number alterations by in silico modelling of somatic genome evolutionTERT-CLPTM1L polymorphism rs401681 contributes to cancers risk: evidence from a meta-analysis based on 29 publicationsTelomeres and telomere dynamics: relevance to cancers of the GI tractOxidative stress induces persistent telomeric DNA damage responsible for nuclear morphology change in mammalian cellsThe patterns and dynamics of genomic instability in metastatic pancreatic cancerCancer biomarker discovery: the entropic hallmark.Telomerase deficiency affects the formation of chromosomal translocations by homologous recombination in Saccharomyces cerevisiae.Correlation of telomere length shortening with promoter methylation profile of p16/Rb and p53/p21 pathways in breast cancer.Telomere DNA content in prostate biopsies predicts early rise in prostate-specific antigen after radical prostatectomy for prostate cancerMechanisms and consequences of aneuploidy and chromosome instability in the aging brainc-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus.Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity.HTLV-1 positive and negative T cells cloned from infected individuals display telomerase and telomere genes deregulation that predominate in activated but untransformed CD4+ T cells.How do tumors make ends meet?Increased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell lineABO blood group and other genetic variants associated with pancreatic cancer.Bayesian Hidden Markov Modeling of Array CGH DataTelomere loss as a mechanism for chromosome instability in human cancerAltered mRNA expression of telomere-associated genes in monoclonal gammopathy of undetermined significance and multiple myeloma.Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cellsShattered and stitched chromosomes-chromothripsis and chromoanasynthesis-manifestations of a new chromosome crisis?Genomic instability and telomere fusion of canine osteosarcoma cells.Telomerase-dependent and independent telomere maintenance and its clinical implications in medullary thyroid carcinoma.Telomere deficiencies on chromosomes 9p, 15p, 15q and Xp: potential biomarkers for breast cancer riskHTLV-1 propels untransformed CD4 lymphocytes into the cell cycle while protecting CD8 cells from death.Shorter telomere length in peripheral blood leukocytes is associated with childhood autism.Telomeres, chromosome instability and cancerThe role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line.DNA double-strand breaks coupled with PARP1 and HNRNPA2B1 binding sites flank coordinately expressed domains in human chromosomesMolecular characteristics of pancreatic ductal adenocarcinomaDNA amplification by breakage/fusion/bridge cycles initiated by spontaneous telomere loss in a human cancer cell line.High-resolution characterization of the pancreatic adenocarcinoma genome.
P2860
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P2860
Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors.
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Telomere dysfunction triggers ...... ies in human malignant tumors.
@ast
Telomere dysfunction triggers ...... ies in human malignant tumors.
@en
type
label
Telomere dysfunction triggers ...... ies in human malignant tumors.
@ast
Telomere dysfunction triggers ...... ies in human malignant tumors.
@en
prefLabel
Telomere dysfunction triggers ...... ies in human malignant tumors.
@ast
Telomere dysfunction triggers ...... ies in human malignant tumors.
@en
P2093
P2860
P356
P1476
Telomere dysfunction triggers ...... ies in human malignant tumors.
@en
P2093
A Petersén
B Strömbeck
D Gisselsson
F Mitelman
P2860
P304
12683-12688
P356
10.1073/PNAS.211357798
P407
P577
2001-10-02T00:00:00Z