STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
about
MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascadesSingle nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotidesCyclic di-GMP sensing via the innate immune signaling protein STINGAncient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune systemRecognition of cytosolic DNA by cGAS and other STING-dependent sensorsStructural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGASCyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced OligomerizationThe Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation LoopInnate immune detection of microbial nucleic acids.Evasion of host immune defenses by human papillomavirusInnate immune recognition of DNA: A recent historyInternational Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and diseaseBacterial recognition pathways that lead to inflammasome activationCyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNARat and human STINGs profile similarly towards anticancer/antiviral compoundsViral evasion of intracellular DNA and RNA sensingThe helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune responseInduction of interferon-stimulated genes by IRF3 promotes replication of Toxoplasma gondiiAge-enhanced endoplasmic reticulum stress contributes to increased Atg9A inhibition of STING-mediated IFN-β production during Streptococcus pneumoniae infectionThe mammalian PYHIN gene family: phylogeny, evolution and expressionNLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STINGNonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation.RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanismsCrosstalk Between Apoptosis and Autophagy: Environmental Genotoxins, Infection, and Innate Immunity.Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1RAD51 interconnects between DNA replication, DNA repair and immunity.Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STINGListeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway.Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acidNEMO binds ubiquitinated TANK-binding kinase 1 (TBK1) to regulate innate immune responses to RNA viruses.A STING-dependent innate-sensing pathway mediates resistance to corneal HSV-1 infection via upregulation of the antiviral effector tetherinHydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs.Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMPThe mechanism of double-stranded DNA sensing through the cGAS-STING pathwayIKKβ is an IRF5 kinase that instigates inflammationMesenchymal stem cells detect and defend against gammaherpesvirus infection via the cGAS-STING pathway.Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathwaysE2 proteins of high risk human papillomaviruses down-modulate STING and IFN-κ transcription in keratinocytes.
P2860
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P2860
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
description
2012 nî lūn-bûn
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2012 թուականի Մարտին հրատարակուած գիտական յօդուած
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2012 թվականի մարտին հրատարակված գիտական հոդված
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年學術文章
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name
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
@ast
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
@en
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
@nl
type
label
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
@ast
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
@en
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
@nl
prefLabel
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
@ast
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
@en
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
@nl
P2860
P921
P1433
P1476
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
@en
P2093
Yasuo Tanaka
Zhijian J Chen
P2860
P356
10.1126/SCISIGNAL.2002521
P577
2012-03-06T00:00:00Z