Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation.
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Dysregulated metabolism contributes to oncogenesisIs cancer a metabolic disease?Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling PathwayTargeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancerPhosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cellsReactive oxygen species are required for driving efficient and sustained aerobic glycolysis during CD4+ T cell activation.Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step.Regulation of endothelial cell metabolism: just go with the flow.Structure-based design of small-molecule ligands of phosphofructokinase-2 activating or inhibiting glycolysis.The expression pattern of PFKFB3 enzyme distinguishes between induced-pluripotent stem cells and cancer stem cells.A Molecular Signature of Myalgia in Myotonic Dystrophy 2Type 2 Diabetes Dysregulates Glucose Metabolism in Cardiac Progenitor CellsOriginal Research: Different imiquimod creams resulting in differential effects for imiquimod-induced psoriatic mouse models.TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemiaNormalization of CD4+ T cell metabolism reverses lupusGlycolytic genes in cancer cells are more than glucose metabolic regulators.Metabolism of stromal and immune cells in health and disease.Fine tuning of immunometabolism for the treatment of rheumatic diseases.Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantationPFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense.Short Term Hypoxia Synergizes with Interleukin 15 Priming in Driving Glycolytic Gene Transcription and Supports Human Natural Killer Cell ActivitiesHIF-1α and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages.Incomplete and transitory decrease of glycolysis: a new paradigm for anti-angiogenic therapy?Inhibition of 6-phosphofructo-2-kinase suppresses fibroblast-like synoviocytes-mediated synovial inflammation and joint destruction in rheumatoid arthritis.The spectrum of T cell metabolism in health and disease.Tumor vessel disintegration by maximum tolerable PFKFB3 blockade.PFKFB3, a Direct Target of p63, Is Required for Proliferation and Inhibits Differentiation in Epidermal Keratinocytes.Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis.PFK15, a PFKFB3 antagonist, inhibits autophagy and proliferation in rhabdomyosarcoma cells.Changes in Nutritional Status Impact Immune Cell Metabolism and Function.
P2860
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P2860
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation.
description
2012 nî lūn-bûn
@nan
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation.
@ast
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation.
@en
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation.
@nl
type
label
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation.
@ast
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation.
@en
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation.
@nl
prefLabel
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation.
@ast
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation.
@en
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation.
@nl
P2093
P2860
P356
P1476
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation.
@en
P2093
Alden C Klarer
Amy L Clem
Brian F Clem
Jason Chesney
John O Trent
Sucheta Telang
P2860
P2888
P356
10.1186/1479-5876-10-95
P577
2012-05-16T00:00:00Z