Human CST promotes telomere duplex replication and general replication restart after fork stalling. - Test2 - elhamkhani - TriplyDB

Human CST promotes telomere duplex replication and general replication restart after fork stalling.

Human CST promotes telomere duplex replication and general replication restart after fork stalling.

http://www.wikidata.org/entity/Q34292284

about

Telomere- and Telomerase-Associated Proteins and Their Functions in the Plant Cell Structure and function of the telomeric CST complex Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy Structure of the Human Telomeric Stn1-Ten1 Capping Complex The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening Telomere DNA recognition in Saccharomycotina yeast: potential lessons for the co-evolution of ssDNA and dsDNA-binding proteins and their target sites Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity Cell biology of disease: Telomeropathies: an emerging spectrum disorder The telomere capping complex CST has an unusual stoichiometry, makes multipartite interaction with G-Tails, and unfolds higher-order G-tail structures The Drosophila telomere-capping protein Verrocchio binds single-stranded DNA and protects telomeres from DNA damage response.MERISTEM DISORGANIZATION1 encodes TEN1, an essential telomere protein that modulates telomerase processivity in Arabidopsis.Fission yeast Stn1 is crucial for semi-conservative replication at telomeres and subtelomeres.Telomeres in health and disease.CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance.Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair.Telomere Biology-Insights into an Intriguing Phenomenon.Human CST has independent functions during telomere duplex replication and C-strand fill-in Telomere stability and development of ctc1 mutants are rescued by inhibition of EJ recombination pathways in a telomerase-dependent manner.TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.Developmental regulation of the Tetrahymena thermophila origin recognition complex.Analysis of poly(ADP-Ribose) polymerases in Arabidopsis telomere biology.Role of STN1 and DNA polymerase α in telomere stability and genome-wide replication in Arabidopsis.POT1a and components of CST engage telomerase and regulate its activity in Arabidopsis.The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch.Stn1 is critical for telomere maintenance and long-term viability of somatic human cells.Evolution of the Telomere-Associated Protein POT1a in Arabidopsis thaliana Is Characterized by Positive Selection to Reinforce Protein-Protein Interaction AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance Checkpoint Activation of an Unconventional DNA Replication Program in Tetrahymena Flap Endonuclease 1 Limits Telomere Fragility on the Leading Strand Gene amplification during differentiation of mammalian neural stem cells in vitro and in vivo.Identification of Genes That Modulate Susceptibility to Formaldehyde and Imatinib by Functional Genomic Screening in Human Haploid KBM7 Cells.A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis.Tying up the Ends: Plasticity in the Recognition of Single-Stranded DNA at Telomeres.STN1 OB Fold Mutation Alters DNA Binding and Affects Selective Aspects of CST Function.Human CST abundance determines recovery from diverse forms of DNA damage and replication stress.Organization and Evolution of Drosophila Terminin: Similarities and Differences between Drosophila and Human Telomeres.DNA repair at telomeres: keeping the ends intact.Suppression of STN1 enhances the cytotoxicity of chemotherapeutic agents in cancer cells by elevating DNA damage.Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.

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P2860

Human CST promotes telomere duplex replication and general replication restart after fork stalling.

http://www.wikidata.org/entity/Q34292284

description

2012 nî lūn-bûn

@nan

2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

Human CST promotes telomere du ...... n restart after fork stalling.

@ast

Human CST promotes telomere du ...... n restart after fork stalling.

@en

Human CST promotes telomere du ...... n restart after fork stalling.

@nl

type

label

Human CST promotes telomere du ...... n restart after fork stalling.

@ast

Human CST promotes telomere du ...... n restart after fork stalling.

@en

Human CST promotes telomere du ...... n restart after fork stalling.

@nl

prefLabel

Human CST promotes telomere du ...... n restart after fork stalling.

@ast

Human CST promotes telomere du ...... n restart after fork stalling.

@en

Human CST promotes telomere du ...... n restart after fork stalling.

@nl

P1433

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P577

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P932

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P1433

The EMBO Journal

P1476

Human CST promotes telomere du ...... n restart after fork stalling.

@en

P2093

Carolyn M Price

http://www.w3.org/2001/XMLSchema#string

Christopher Kasbek

http://www.w3.org/2001/XMLSchema#string

Jason A Stewart

http://www.w3.org/2001/XMLSchema#string

Mary F Chaiken

http://www.w3.org/2001/XMLSchema#string

Paul D Chastain

http://www.w3.org/2001/XMLSchema#string

P2860

TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase

RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway

Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes

OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein

Cdc13 delivers separate complexes to the telomere for end protection and replication.

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping

P304

3537-3549

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scholarly article

P356

10.1038/EMBOJ.2012.215

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P433

17

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31

http://www.w3.org/2001/XMLSchema#string

P50

Woodring E. Wright

P577

2012-08-03T00:00:00Z

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P5875

230618859

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P698

22863775

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P932

3433780

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