TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling. - Test2 - elhamkhani - TriplyDB

TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.

TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.

http://www.wikidata.org/entity/Q34518947

about

Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies Replication of Structured DNA and its implication in epigenetic stability ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres Re-evaluation of G-quadruplex propensity with G4Hunter RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends The telomeric DNA damage response occurs in the absence of chromatin decompaction Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands.Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage.Interactive Roles of DNA Helicases and Translocases with the Single-Stranded DNA Binding Protein RPA in Nucleic Acid Metabolism.BLM unfolds G-quadruplexes in different structural environments through different mechanisms Mre11 and Blm-Dependent Formation of ALT-Like Telomeres in Ku-Deficient Ustilago maydis.A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis.Accumulation and Phosphorylation of RecQ-Mediated Genome Instability Protein 1 (RMI1) at Serine 284 and Serine 292 during Mitosis.SMARCAL1 maintains telomere integrity during DNA replication.Complex interactions between the DNA-damage response and mammalian telomeres.Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.TINF2 Gene Mutation in a Patient with Pulmonary Fibrosis.E-type cyclins modulate telomere integrity in mammalian male meiosis Fanconi anemia proteins in telomere maintenance.The molecular genetics of the telomere biology disorders.Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase δ Elongation.Stop pulling my strings - what telomeres taught us about the DNA damage response.Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity Getting it done at the ends: Pif1 family DNA helicases and telomeres.Solving the Telomere Replication Problem.Regulation of DNA Replication through Natural Impediments in the Eukaryotic Genome.DNA Replication Origins and Fork Progression at Mammalian Telomeres Yeast Hrq1 shares structural and functional homology with the disease-linked human RecQ4 helicase.Sgs1's roles in DNA end resection, HJ dissolution, and crossover suppression require a two-step SUMO regulation dependent on Smc5/6.Early Loss of Telomerase Action in Yeast Creates a Dependence on the DNA Damage Response Adaptor Proteins.Aurora Kinase B, a novel regulator of TERF1 binding and telomeric integrity.RecQ and Fe-S helicases have unique roles in DNA metabolism dictated by their unwinding directionality, substrate specificity, and protein interactions.Contributions of recombination and repair proteins to telomere maintenance in telomerase-positive and negative Ustilago maydis.TRF2 binds branched DNA to safeguard telomere integrity.TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops.FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres.Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer.

P2860

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P2860

TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.

http://www.wikidata.org/entity/Q34518947

description

2014 nî lūn-bûn

@nan

2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

TRF1 negotiates TTAGGG repeat- ...... T1 repressor of ATR signaling.

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TRF1 negotiates TTAGGG repeat- ...... T1 repressor of ATR signaling.

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TRF1 negotiates TTAGGG repeat- ...... T1 repressor of ATR signaling.

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TRF1 negotiates TTAGGG repeat- ...... T1 repressor of ATR signaling.

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TRF1 negotiates TTAGGG repeat- ...... T1 repressor of ATR signaling.

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TRF1 negotiates TTAGGG repeat- ...... T1 repressor of ATR signaling.

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TRF1 negotiates TTAGGG repeat- ...... T1 repressor of ATR signaling.

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Genes & Development

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TRF1 negotiates TTAGGG repeat- ...... T1 repressor of ATR signaling.

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Michal Zimmermann

http://www.w3.org/2001/XMLSchema#string

Shaheen Kabir

http://www.w3.org/2001/XMLSchema#string

Tatsuya Kibe

http://www.w3.org/2001/XMLSchema#string

P2860

TIN2, a new regulator of telomere length in human cells

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2

POT1 as a terminal transducer of TRF1 telomere length control

A human telomeric protein

The Werner and Bloom syndrome proteins catalyze regression of a model replication fork

TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes

Telomere protection by mammalian Pot1 requires interaction with Tpp1

Shelterin complex and associated factors at human telomeres

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2477-2491

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10.1101/GAD.251611.114

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22

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28

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267744139

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25344324

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4233241

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