Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
about
Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substratesHyperactivation of DNA-PK by double-strand break mimicking molecules disorganizes DNA damage responseNondisjunction of a single chromosome leads to breakage and activation of DNA damage checkpoint in G2Shelterin-like proteins and Yku inhibit nucleolytic processing of Saccharomyces cerevisiae telomeresChk1 suppressed cell deathHuman single-stranded DNA binding proteins are essential for maintaining genomic stabilityPhosphorylation: the molecular switch of double-strand break repairInfluence of light on aryl hydrocarbon receptor signaling and consequences in drug metabolism, physiology and diseaseTel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexesStructure of RPA32 bound to the N-terminus of SMARCAL1 redefines the binding interface between RPA32 and its interacting proteinsE3 ligase RFWD3 participates in replication checkpoint controlMSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylationCyclin-dependent kinase 9-cyclin K functions in the replication stress responseInteraction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cellsCtIP is required to initiate replication-dependent interstrand crosslink repairCoordination of DNA damage responses via the Smc5/Smc6 complexA genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stabilityProteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stressCellular functions of human RPA1. Multiple roles of domains in replication, repair, and checkpointsRAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylationPRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitryDNA nucleotide excision repair-dependent signaling to checkpoint activationInteraction between human MCM7 and Rad17 proteins is required for replication checkpoint signalingRecognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forksN terminus of CtIP is critical for homologous recombination-mediated double-strand break repairCdc5L interacts with ATR and is required for the S-phase cell-cycle checkpointSumoylation of the novel protein hRIP{beta} is involved in replication protein A deposition in PML nuclear bodiesThe SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restartHuman UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replicationMCM-BP regulates unloading of the MCM2-7 helicase in late S phasePALB2 regulates recombinational repair through chromatin association and oligomerizationMiz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1An alternative form of replication protein a expressed in normal human tissues supports DNA repairATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adductsA genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repairPOT1 and TRF2 cooperate to maintain telomeric integrity14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damageFunctional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylationPPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
P2860
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P2860
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
@ast
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
@en
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
@nl
type
label
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
@ast
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
@en
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
@nl
prefLabel
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
@ast
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
@en
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
@nl
P3181
P356
P1433
P1476
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
@en
P2093
P304
P3181
P356
10.1126/SCIENCE.1083430
P407
P577
2003-06-06T00:00:00Z