Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia. - Test2 - elhamkhani - TriplyDB

Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.

Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.

http://www.wikidata.org/entity/Q34307027

about

Prognostic role of microRNA-150 in various carcinomas: a meta-analysis MYC and the art of microRNA maintenance c-MYC-miRNA circuitry: a central regulator of aggressive B-cell malignancies MicroRNAs in B-cell lymphomas: how a complex biology gets more complex Lin28: primal regulator of growth and metabolism in stem cells Ectopic microRNA-150-5p transcription sensitizes glucocorticoid therapy response in MM1S multiple myeloma cells but fails to overcome hormone therapy resistance in MM1R cells MiR-150 impairs inflammatory cytokine production by targeting ARRB-2 after blocking CD28/B7 costimulatory pathway.miR-150 is downregulated in osteosarcoma and suppresses cell proliferation, migration and invasion by targeting ROCK1.ALOX5 exhibits anti-tumor and drug-sensitizing effects in MLL-rearranged leukemia.miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia MicroRNA-150 regulates the cytotoxicity of natural killers by targeting perforin-1 MicroRNAs in Cancer Biology and Therapy: Current Status and Perspectives.Repression of let-7 by transforming growth factor-β1-induced Lin28 upregulates collagen expression in glomerular mesangial cells under diabetic conditions.Flt3 does not play a critical role in murine myeloid leukemias induced by MLL fusion genes.MicroRNA-150 expression induces myeloid differentiation of human acute leukemia cells and normal hematopoietic progenitors Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.A microRNA signature predicts survival in early stage small-cell lung cancer treated with surgery and adjuvant chemotherapy.Human fibroblast reprogramming to pluripotent stem cells regulated by the miR19a/b-PTEN axis.Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.The pathological role and prognostic impact of miR-181 in acute myeloid leukemia Role of microRNA-150 in solid tumors.microRNA-150 promotes cervical cancer cell growth and survival by targeting FOXO4.Emerging role of transcription factor-microRNA-target gene feed-forward loops in cancer.Reversal of microRNA-150 silencing disadvantages crizotinib-resistant NPM-ALK(+) cell growth Overexpression and knockout of miR-126 both promote leukemogenesis CD46 Activation Regulates miR-150-Mediated Control of GLUT1 Expression and Cytokine Secretion in Human CD4+ T Cells.PBX3 is an important cofactor of HOXA9 in leukemogenesis.Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study.Identification of MLL-fusion/MYC⊣miR-26⊣TET1 signaling circuit in MLL-rearranged leukemia.PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferation.miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis.miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia.TET1 plays an essential oncogenic role in MLL-rearranged leukemia Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis.Differential regulation of the c-Myc/Lin28 axis discriminates subclasses of rearranged MLL leukemia miR-150 exerts antileukemia activity in vitro and in vivo through regulating genes in multiple pathways Synthesis and delivery of short, noncoding RNA by B lymphocytes.miR-150 Suppresses the Proliferation and Tumorigenicity of Leukemia Stem Cells by Targeting the Nanog Signaling Pathway.HSC commitment-associated epigenetic signature is prognostic in acute myeloid leukemia.

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P2860

Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.

http://www.wikidata.org/entity/Q34307027

description

2012 nî lūn-bûn

@nan

2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Blockade of miR-150 maturation ...... d for MLL-associated leukemia.

@ast

Blockade of miR-150 maturation ...... d for MLL-associated leukemia.

@en

Blockade of miR-150 maturation ...... d for MLL-associated leukemia.

@nl

type

label

Blockade of miR-150 maturation ...... d for MLL-associated leukemia.

@ast

Blockade of miR-150 maturation ...... d for MLL-associated leukemia.

@en

Blockade of miR-150 maturation ...... d for MLL-associated leukemia.

@nl

prefLabel

Blockade of miR-150 maturation ...... d for MLL-associated leukemia.

@ast

Blockade of miR-150 maturation ...... d for MLL-associated leukemia.

@en

Blockade of miR-150 maturation ...... d for MLL-associated leukemia.

@nl

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J.CCR.2012.08.028

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Blockade of miR-150 maturation ...... d for MLL-associated leukemia.

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Abdel Elkahloun

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Chuan He

http://www.w3.org/2001/XMLSchema#string

Chunjiang He

http://www.w3.org/2001/XMLSchema#string

Colles Price

http://www.w3.org/2001/XMLSchema#string

Dewen You

http://www.w3.org/2001/XMLSchema#string

Gia-Ming Hong

http://www.w3.org/2001/XMLSchema#string

Hao Huang

http://www.w3.org/2001/XMLSchema#string

Haomin Ren

http://www.w3.org/2001/XMLSchema#string

Jianjun Chen

http://www.w3.org/2001/XMLSchema#string

Jinhua Wang

http://www.w3.org/2001/XMLSchema#string

P2860

Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA

MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

Significance analysis of microarrays applied to the ionizing radiation response

Selective blockade of microRNA processing by Lin28

Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications

Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

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524-535

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10.1016/J.CCR.2012.08.028

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4

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22

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23079661

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3480215

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