A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia. - Test2 - elhamkhani - TriplyDB

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q34315750

about

MYC, Metabolism, and Cancer Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine Emerging concepts of epigenetic dysregulation in hematological malignancies The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia Controlling the Master: Chromatin Dynamics at the MYC Promoter Integrate Developmental Signaling Efficient chromosomal-scale DNA looping in Escherichia coli using multiple DNA-looping elements Systematic mapping of functional enhancer-promoter connections with CRISPR interference.Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth.MYC Deregulation in Primary Human Cancers.Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers.SEA: a super-enhancer archive.Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers.The role of Notch receptors in transcriptional regulation Direct ChIP-Seq significance analysis improves target prediction.High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.Preclinical Models Provide Scientific Justification and Translational Relevance for Moving Novel Therapeutics into Clinical Trials for Pediatric Cancer.Super Enhancers in Cancers, Complex Disease, and Developmental Disorders.Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis.Modulation of tissue repair by regeneration enhancer elements.Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia.Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the γ-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case.MYC activation and BCL2L11 silencing by a tumour virus through the large-scale reconfiguration of enhancer-promoter hubs.Epigenetics of hematopoiesis and hematological malignancies.Small genomic insertions form enhancers that misregulate oncogenes MYC in Regulating Immunity: Metabolism and Beyond.c-Myc-Induced Survivin Is Essential for Promoting the Notch-Dependent T Cell Differentiation from Hematopoietic Stem Cells.Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands.Genomics in acute lymphoblastic leukaemia: insights and treatment implications.Drugging Chromatin in Cancer: Recent Advances and Novel Approaches.Driving Toward Precision Medicine for Acute Leukemias: Are We There Yet?β-Catenin is required for T-cell leukemia initiation and MYC transcription downstream of Notch1.Genome-wide identification and characterization of Notch transcription complex-binding sequence-paired sites in leukemia cells.Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disorders.Enhancer deregulation in cancer and other diseases.Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma.Deregulation of the non-coding genome in leukemia.ChIP-seq in studying epigenetic mechanisms of disease and promoting precision medicine: progresses and future directions.Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia.Therapeutic target discovery and drug development in cancer stem cells for leukemia and lymphoma: from bench to the clinic.

P2860

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P2860

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q34315750

description

2014 nî lūn-bûn

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2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

A NOTCH1-driven MYC enhancer p ...... acute lymphoblastic leukemia.

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A NOTCH1-driven MYC enhancer p ...... acute lymphoblastic leukemia.

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A NOTCH1-driven MYC enhancer p ...... acute lymphoblastic leukemia.

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A NOTCH1-driven MYC enhancer p ...... acute lymphoblastic leukemia.

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A NOTCH1-driven MYC enhancer p ...... acute lymphoblastic leukemia.

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A NOTCH1-driven MYC enhancer p ...... acute lymphoblastic leukemia.

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A NOTCH1-driven MYC enhancer p ...... acute lymphoblastic leukemia.

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A NOTCH1-driven MYC enhancer p ...... acute lymphoblastic leukemia.

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A NOTCH1-driven MYC enhancer p ...... acute lymphoblastic leukemia.

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Nature Medicine

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A NOTCH1-driven MYC enhancer p ...... acute lymphoblastic leukemia.

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Adolfo A Ferrando

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Agnieszka A Wendorff

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Daniel Herranz

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David Llobet-Navás

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Emmanuelle Clappier

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Jean Soulier

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Laura Belver

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Luyao Xu

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Mireia Castillo-Martin

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Stephanie A Schnell

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P2860

Mouse estrous cycle identification tool and images

A user's guide to the encyclopedia of DNA elements (ENCODE)

Model-based analysis of ChIP-Seq (MACS)

Identification of c-MYC as a target of the APC pathway

Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

Genome-wide association study identifies novel breast cancer susceptibility loci

An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

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10.1038/NM.3665

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10

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20

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Carlos Cordon-Cardo

Alberto Ambesi-Impiombato

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2014-09-07T00:00:00Z

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25194570

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