The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation
about
New insights into an X-traordinary viral proteinMechanism of allosteric activation of SAMHD1 by dGTPStructural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolaseRegulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implicationsThe Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T CellsFunctional organization of human SAMHD1 and mechanisms of HIV-1 restrictionThe ribonuclease activity of SAMHD1 is required for HIV-1 restrictionMacaques as model hosts for studies of HIV-1 infectionModerate restriction of macrophage-tropic human immunodeficiency virus type 1 by SAMHD1 in monocyte-derived macrophages.Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1A cell-intrinsic inhibitor of HIV-1 reverse transcription in CD4(+) T cells from elite controllersEffects of human SAMHD1 polymorphisms on HIV-1 susceptibility.SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitorsMxB binds to the HIV-1 core and prevents the uncoating process of HIV-1Mouse knockout models for HIV-1 restriction factors.dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.Phosphodiesterase 8a supports HIV-1 replication in macrophages at the level of reverse transcriptionModulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutières syndrome-related SAMHD1.Structural basis of cellular dNTP regulation by SAMHD1.SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.SAMHD1 prevents autoimmunity by maintaining genome stability.The eukaryotic elongation factor eEF1A1 interacts with SAMHD1.SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activityMicroRNA-181 contributes to downregulation of SAMHD1 expression in CD4+ T-cells derived from Sèzary syndrome patients.Substrates and Inhibitors of SAMHD1.Structural basis of allosteric activation of sterile α motif and histidine-aspartate domain-containing protein 1 (SAMHD1) by nucleoside triphosphates.Dendritic cells in progression and pathology of HIV infection.Cyclin L2 is a critical HIV dependency factor in macrophages that controls SAMHD1 abundance.SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells.Low SAMHD1 expression following T-cell activation and proliferation renders CD4+ T cells susceptible to HIV-1.Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx.SAMHD1 specifically restricts retroviruses through its RNase activity.SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation.Subversion of Cell Cycle Regulatory Mechanisms by HIV.Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction.The Frequency of Cytidine Editing of Viral DNA Is Differentially Influenced by Vpx and Nucleosides during HIV-1 or SIVMAC Infection of Dendritic Cells.CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain.SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activitySulforaphane Inhibits HIV Infection of Macrophages through Nrf2.Reduced Simian Immunodeficiency Virus Replication in Macrophages of Sooty Mangabeys Is Associated with Increased Expression of Host Restriction Factors.
P2860
Q21131105-9CC4CC5D-5C4B-46A2-B116-447B0A7F1A52Q24338757-B61357C7-93EE-4603-92D1-1F6E5736ED84Q24339547-685C4993-3A87-4B81-A0F5-995EF6E91FD2Q26785350-117189D8-3484-4286-89EC-515282A548C8Q27319577-2B367287-10C1-4C53-8897-991DE9EAE2C1Q28073284-F1087DE2-95E7-4D2F-90BD-1BA567EAE246Q29147390-2CE1A1FB-8287-4246-A32C-EC1590B7C95BQ30653348-36EC2223-B97F-4F11-BDBB-059BF093BF04Q31153030-74E034FE-D341-4C45-9918-1CF54503762DQ33602815-2DD4FBA1-4310-4080-87E0-832D1894EB00Q33811660-BD408AC3-0E9F-4331-8151-E8DD1E64968CQ33911427-39CB5E92-50F2-42AB-8F50-58A6C4C85704Q34058270-47303781-8C6C-4EB3-B6DD-D9ABAFB53544Q34091405-5B84AE2E-237D-4E0B-AF14-3DAB63785DD2Q34161853-45D4D7A5-6CB3-4011-BE49-4CFE70EAD10AQ34169187-DE4CFF1F-7612-438E-A50C-ACDDBEDB12DFQ34309051-47DB0FAD-A9A8-4718-8795-03334C41EABEQ34371066-252361EE-ED82-4481-8C41-8EF9A10468D5Q34383850-39DF2D45-2008-4500-83B3-0FF99CD448B4Q34391609-2D294F8F-58B8-4D49-97A3-4B30BD4FE3F8Q34399058-A52CD470-1C7A-4B48-A324-354047F80865Q34449466-A9667FD1-C73C-4356-A387-12606BA9E5F7Q34542134-E516B573-0481-4798-BE90-36E609ABFA63Q34545956-BEFEA431-B3E5-4664-887F-3EAFB1496DEDQ34548496-212EBE29-8381-4B6F-A1F5-C6466E536599Q34552616-4C140157-2530-463F-8360-C45E7A2A49A5Q34657557-FB9AE2B8-8EB3-4F79-8D4F-55D6A6616D28Q34667185-A31A2FB3-D675-49B1-B8B7-0D5927E403ACQ35107612-D3C53D7B-AA6C-4DB3-B441-C416117D88CBQ35126450-2246D25C-D8CE-49C7-B587-09E12360F789Q35450431-0948E612-EF0B-4C32-A804-14521632748DQ35670483-1ACD47A8-377D-4172-B483-3CE42826A4D8Q35680916-61BE9DD6-59D5-4DBE-AB37-FABBE1AF61A9Q35767091-8735DDB2-D785-4430-83EF-FC2B5C91A518Q35796953-5785325F-D850-4B14-BF77-2AF01477F8F2Q35819276-D8B6F044-F5AE-4473-BFE1-50D6DA068ECFQ35860974-0AA510E4-B355-4122-91B7-70F4BEDCD4D0Q35885990-09220681-FB45-49B8-863B-FFDC5B931AB4Q35993749-4A2179BB-1E38-4806-8A1C-D4C6437834DDQ36086267-C4A23721-53F9-4BCA-A444-D5A565C4FB74
P2860
The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation
description
2013 nî lūn-bûn
@nan
2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
The retroviral restriction abi ...... s regulated by phosphorylation
@ast
The retroviral restriction abi ...... s regulated by phosphorylation
@en
The retroviral restriction abi ...... s regulated by phosphorylation
@nl
type
label
The retroviral restriction abi ...... s regulated by phosphorylation
@ast
The retroviral restriction abi ...... s regulated by phosphorylation
@en
The retroviral restriction abi ...... s regulated by phosphorylation
@nl
prefLabel
The retroviral restriction abi ...... s regulated by phosphorylation
@ast
The retroviral restriction abi ...... s regulated by phosphorylation
@en
The retroviral restriction abi ...... s regulated by phosphorylation
@nl
P2093
P2860
P921
P1433
P1476
The retroviral restriction abi ...... s regulated by phosphorylation
@en
P2093
Alberto Brandariz-Nuñez
Felipe Diaz-Griffero
Jose Carlos Valle-Casuso
Laura Anh Nguyen
Marina Tuzova
Sarah Amie
Tommy E White
P2860
P304
P356
10.1016/J.CHOM.2013.03.005
P577
2013-04-01T00:00:00Z