SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations
about
New insights into an X-traordinary viral proteinIdentification and characterization of naturally occurring splice variants of SAMHD1Mechanism of allosteric activation of SAMHD1 by dGTPSAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cellsMouse models for Aicardi-Goutières syndrome provide clues to the molecular pathogenesis of systemic autoimmunityThe ribonuclease activity of SAMHD1 is required for HIV-1 restrictionIdentification of cellular proteins interacting with the retroviral restriction factor SAMHD1SAMHD1 protects cancer cells from various nucleoside-based antimetabolites.Nuclear import of SAMHD1 is mediated by a classical karyopherin α/β1 dependent pathway and confers sensitivity to VpxMAC induced ubiquitination and proteasomal degradation.Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.Mouse knockout models for HIV-1 restriction factors.dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction.The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylationThe eukaryotic elongation factor eEF1A1 interacts with SAMHD1.SAMHD1 specifically restricts retroviruses through its RNase activity.Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction.SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activityRole of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac.Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592Phosphorylation of murine SAMHD1 regulates its antiretroviral activityFunctional analysis of the relationship between Vpx and the restriction factor SAMHD1.Host restriction factors in retroviral infection: promises in virus-host interaction.Low dNTP levels are necessary but may not be sufficient for lentiviral restriction by SAMHD1.Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradationEffects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect.Restriction of virus infection but not catalytic dNTPase activity is regulated by phosphorylation of SAMHD1.SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication.HIV accessory proteins versus host restriction factors.Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1.SAMHD1: a novel antiviral factor in intrinsic immunity.Aicardi-Goutières syndrome: a model disease for systemic autoimmunity.Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation: The Curious Case of HIV-1.Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer.HIV suppression by host restriction factors and viral immune evasion.Type I interferonopathies--an expanding disease spectrum of immunodysregulation.The druggability of intracellular nucleotide-degrading enzymes.
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P2860
SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
SAMHD1 is a nucleic-acid bindi ...... syndrome-associated mutations
@ast
SAMHD1 is a nucleic-acid bindi ...... syndrome-associated mutations
@en
SAMHD1 is a nucleic-acid bindi ...... syndrome-associated mutations
@en-gb
SAMHD1 is a nucleic-acid bindi ...... syndrome-associated mutations
@nl
type
label
SAMHD1 is a nucleic-acid bindi ...... syndrome-associated mutations
@ast
SAMHD1 is a nucleic-acid bindi ...... syndrome-associated mutations
@en
SAMHD1 is a nucleic-acid bindi ...... syndrome-associated mutations
@en-gb
SAMHD1 is a nucleic-acid bindi ...... syndrome-associated mutations
@nl
prefLabel
SAMHD1 is a nucleic-acid bindi ...... syndrome-associated mutations
@ast
SAMHD1 is a nucleic-acid bindi ...... syndrome-associated mutations
@en
SAMHD1 is a nucleic-acid bindi ...... syndrome-associated mutations
@en-gb
SAMHD1 is a nucleic-acid bindi ...... syndrome-associated mutations
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
SAMHD1 is a nucleic-acid bindi ...... syndrome-associated mutations
@en
P2093
Adriana Goncalves
Evren Karayel
Keiryn L Bennett
P2860
P304
P3181
P356
10.1002/HUMU.22087
P407
P577
2012-07-01T00:00:00Z