TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells.
about
The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulatorsHeparan sulfate signaling in cancerSIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.The differential spatiotemporal expression pattern of shelterin genes throughout lifespanERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2.A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.Over-expression of telomere binding factors (TRF1 & TRF2) in renal cell carcinoma and their inhibition by using SiRNA induce apoptosis, reduce cell proliferation and migration invitro.TeloPIN: a database of telomeric proteins interaction network in mammalian cellsBalancing the innate immune system in tumor development.New insights into cancer immunoediting and its three component phases--elimination, equilibrium and escapeThe topoisomerase II catalytic inhibitor ICRF-193 preferentially targets telomeres that are capped by TRF2.Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes.A higher-order entity formed by the flexible assembly of RAP1 with TRF2.TRF2 acts as a transcriptional regulator in tumor angiogenesis.High expression of TRF2, SOX10, and CD10 in circulating tumor microemboli detected in metastatic melanoma patients. A potential impact for the assessment of disease aggressivenessGenome-wide siRNA screen reveals a new cellular partner of NK cell receptor KIR2DL4: heparan sulfate directly modulates KIR2DL4-mediated responses.Heparan sulfation is essential for the prevention of cellular senescence.Telomeric repeat-binding factor 2: a marker for survival and anti-EGFR efficacy in oral carcinomaA novel pathway links telomeres to NK-cell activity: Implications for immunotherapyThe c-Jun N-terminal kinase prevents oxidative stress induced by UV and thermal stresses in corals and human cells.Telomeric impact of conventional chemotherapy.Transcriptional outcome of telomere signalling.Cellular senescence: from growth arrest to immunogenic conversion.Disruption of direct 3D telomere-TRF2 interaction through two molecularly disparate mechanisms is a hallmark of primary Hodgkin and Reed-Sternberg cells.The long and the short of TRF2 in neurogenesis.Telomere-driven diseases and telomere-targeting therapies.Rare germline alterations in cancer-related genes associated with the risk of multiple primary tumor development.Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex.Validation of commercial ERK antibodies against the ERK orthologue of the scleractinian coral Stylophora pistillataDifferential senescence capacities in meibomian gland carcinoma and basal cell carcinoma.Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites.Tailoring Natural Killer cell immunotherapy to the tumour microenvironment.The heparan sulfate 3-O-sulfotransferases (HS3ST) 2, 3B and 4 enhance proliferation and survival in breast cancer MDA-MB-231 cells.The Wilms' tumour suppressor Wt1 is a major regulator of tumour angiogenesis and progression.DNA methylome analysis of acute lymphoblastic leukemia cells reveals stochastic de novo DNA methylation in CpG islands.p38 MAPK pathway and its interaction with TRF2 in cisplatin induced chemotherapeutic response in head and neck cancer.Stem and immune cells in colorectal primary tumour: Number and function of subsets may diagnose metastasisThe Pro-Tumoral Activity of Heparan Sulfate 3--Sulfotransferase 3B (HS3ST3B) in Breast Cancer MDA-MB-231 Cells Is Dependent on the Expression of Neuropilin-1Heparan Sulfate and Heparan Sulfate Proteoglycans in Cancer Initiation and Progression
P2860
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P2860
TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells.
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
TRF2 inhibits a cell-extrinsic ...... cells eliminate cancer cells.
@ast
TRF2 inhibits a cell-extrinsic ...... cells eliminate cancer cells.
@en
TRF2 inhibits a cell-extrinsic ...... cells eliminate cancer cells.
@nl
type
label
TRF2 inhibits a cell-extrinsic ...... cells eliminate cancer cells.
@ast
TRF2 inhibits a cell-extrinsic ...... cells eliminate cancer cells.
@en
TRF2 inhibits a cell-extrinsic ...... cells eliminate cancer cells.
@nl
prefLabel
TRF2 inhibits a cell-extrinsic ...... cells eliminate cancer cells.
@ast
TRF2 inhibits a cell-extrinsic ...... cells eliminate cancer cells.
@en
TRF2 inhibits a cell-extrinsic ...... cells eliminate cancer cells.
@nl
P2093
P2860
P50
P356
P1433
P1476
TRF2 inhibits a cell-extrinsic ...... cells eliminate cancer cells.
@en
P2093
Aaron Mendez-Bermudez
Adeline Augereau
Béatrice Horard
Claire T'kint de Rodenbeeke
Céline Cognet
Daniel Peeper
Delphine Poncet
Els Verhoeyen
Eric Gilson
Florian Lépinasse
P2860
P2888
P304
P356
10.1038/NCB2774
P50
P577
2013-06-23T00:00:00Z
P5875
P6179
1000559822