Shelterin: the protein complex that shapes and safeguards human telomeres
about
Diminished telomeric 3' overhangs are associated with telomere dysfunction in Hoyeraal-Hreidarsson syndromeShelterin-like proteins and Yku inhibit nucleolytic processing of Saccharomyces cerevisiae telomeresATM promotes the obligate XY crossover and both crossover control and chromosome axis integrity on autosomesThe secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulatorsHuman single-stranded DNA binding proteins are essential for maintaining genomic stabilityMassive Horizontal Gene Transfer in Bdelloid RotifersQuadruplex DNA: sequence, topology and structureRNF4 interacts with both SUMO and nucleosomes to promote the DNA damage responseA critical role for TPP1 and TIN2 interaction in high-order telomeric complex assemblyProtein requirements for sister telomere association in human cellsStructural basis of selective ubiquitination of TRF1 by SCFFbx4Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cellsThe human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activityWRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shorteningTelomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongationIdentification of ATPases pontin and reptin as telomerase components essential for holoenzyme assemblyThe SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteinsTRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwindingHuman Dna2 is a nuclear and mitochondrial DNA maintenance proteinTRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent mannerInherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndromeTINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromesOB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulationPinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual rolesTelomere protection by mammalian Pot1 requires interaction with Tpp1POT1 association with TRF2 regulates telomere lengthConstitutional mutations in RTEL1 cause severe dyskeratosis congenitaCharacterization of the DNA binding specificity of Shelterin complexesTelomere dysfunction and cell survival: roles for distinct TIN2-containing complexesc-Myc interacts with TRF1/PIN2 and regulates telomere lengthSuppression of nonhomologous end joining repair by overexpression of HMGA2PinX1 is involved in telomerase recruitment and regulates telomerase function by mediating its localizationThe molecular biology of human herpesvirus-6 latency and telomere integrationShelterin complex and associated factors at human telomeresGenome sequencing reveals insights into physiology and longevity of the naked mole ratTelomeres in diseaseThe DNA-damage response in human biology and diseaseTIN2-tethered TPP1 recruits human telomerase to telomeres in vivoCharacterization of the yeast telomere nucleoprotein core: Rap1 binds independently to each recognition siteEvolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians
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P2860
Shelterin: the protein complex that shapes and safeguards human telomeres
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
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2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Shelterin: the protein complex that shapes and safeguards human telomeres
@ast
Shelterin: the protein complex that shapes and safeguards human telomeres
@en
Shelterin: the protein complex that shapes and safeguards human telomeres
@nl
type
label
Shelterin: the protein complex that shapes and safeguards human telomeres
@ast
Shelterin: the protein complex that shapes and safeguards human telomeres
@en
Shelterin: the protein complex that shapes and safeguards human telomeres
@nl
prefLabel
Shelterin: the protein complex that shapes and safeguards human telomeres
@ast
Shelterin: the protein complex that shapes and safeguards human telomeres
@en
Shelterin: the protein complex that shapes and safeguards human telomeres
@nl
P3181
P356
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P1476
Shelterin: the protein complex that shapes and safeguards human telomeres
@en
P304
P3181
P356
10.1101/GAD.1346005
P407
P577
2005-09-15T00:00:00Z