Sestrins orchestrate cellular metabolism to attenuate aging. - Test2 - elhamkhani - TriplyDB

Sestrins orchestrate cellular metabolism to attenuate aging.

Sestrins orchestrate cellular metabolism to attenuate aging.

http://www.wikidata.org/entity/Q34372569

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Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1 Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling Advances in Autophagy Regulatory Mechanisms Sestrin2, a Regulator of Thermogenesis and Mitohormesis in Brown Adipose Tissue Recent Advances in Understanding Amino Acid Sensing Mechanisms that Regulate mTORC1 Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains Hepatoprotective role of Sestrin2 against chronic ER stress Sestrins inhibit mTORC1 kinase activation through the GATOR complex Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling Sesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling.Microgravity-Induced Transcriptome Adaptation in Mouse Paraspinal longissimus dorsi Muscle Highlights Insulin Resistance-Linked Genes.Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species.Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury Sestrin2 Suppresses Classically Activated Macrophages-Mediated Inflammatory Response in Myocardial Infarction through Inhibition of mTORC1 Signaling.MicroRNAs and Autophagy: Fine Players in the Control of Chondrocyte Homeostatic Activities in Osteoarthritis.NHE1 deficiency in liver: implications for non-alcoholic fatty liver disease.Exercise attenuates the major hallmarks of aging.Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells.Insulin Increases Sestrin 2 Content by Reducing Its Degradation through the PI 3 K/mTOR Signaling Pathway.Upregulation of Sestrin2 expression protects against macrophage apoptosis induced by oxidized low-density lipoprotein.Oxidative stress, redox regulation and diseases of cellular differentiation.Prediction and Validation of Transcription Factors Modulating the Expression of Sestrin3 Gene Using an Integrated Computational and Experimental Approach.The Expression of the Endogenous mTORC1 Inhibitor Sestrin 2 Is Induced by UVB and Balanced with the Expression Level of Sestrin 1.Elongation of Long-Chain Fatty Acid Family Member 6 (Elovl6)-Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP-Activated Protein Kinase/Krüppel-Like Factor 4 (AMPK/KLF4) Signaling Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization.Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death.Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis.Multiple amino acid sensing inputs to mTORC1.Sestrin regulation of TORC1: Is Sestrin a leucine sensor?Nutrient-sensing mTORC1: Integration of metabolic and autophagic signals Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats.SESN2/sestrin 2 induction-mediated autophagy and inhibitory effect of isorhapontigenin (ISO) on human bladder cancers A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging New molecular targets and lifestyle interventions to delay aging sarcopenia.The Intricate Interplay between Mechanisms Underlying Aging and Cancer.Eupatilin induces Sestrin2-dependent autophagy to prevent oxidative stress.Biochemical Basis of Sestrin Physiological Activities.

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Sestrins orchestrate cellular metabolism to attenuate aging.

http://www.wikidata.org/entity/Q34372569

description

2013 nî lūn-bûn

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2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Sestrins orchestrate cellular metabolism to attenuate aging.

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Sestrins orchestrate cellular metabolism to attenuate aging.

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Sestrins orchestrate cellular metabolism to attenuate aging.

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type

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Sestrins orchestrate cellular metabolism to attenuate aging.

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Sestrins orchestrate cellular metabolism to attenuate aging.

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Sestrins orchestrate cellular metabolism to attenuate aging.

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prefLabel

Sestrins orchestrate cellular metabolism to attenuate aging.

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Sestrins orchestrate cellular metabolism to attenuate aging.

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Sestrins orchestrate cellular metabolism to attenuate aging.

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J.CMET.2013.08.018

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Cell Metabolism

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Sestrins orchestrate cellular metabolism to attenuate aging.

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Andrei V Budanov

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Jun Hee Lee

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P2860

Mutations in many genes affect aggressive behavior in Drosophila melanogaster

PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

AMPK phosphorylation of raptor mediates a metabolic checkpoint

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor

mTOR: from growth signal integration to cancer, diabetes and ageing

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Genetic variation for cardiac dysfunction in Drosophila

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scholarly article

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10.1016/J.CMET.2013.08.018

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