Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARα and inhibits the growth of acute promyelocytic leukemia - Test2 - elhamkhani - TriplyDB

Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARα and inhibits the growth of acute promyelocytic leukemia

Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARα and inhibits the growth of acute promyelocytic leukemia

http://www.wikidata.org/entity/Q34393733

about

PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo USP18 is crucial for IFN-γ-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity.Covalent protein modification with ISG15 via a conserved cysteine in the hinge region Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas Evidence for the ubiquitin protease UBP43 as an antineoplastic target.Post-translational modifications of PML: consequences and implications.Retinoids and rexinoids in cancer prevention: from laboratory to clinic.Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN-λ and elevated secretion of Cxcl10 Comparing histone deacetylase inhibitor responses in genetically engineered mouse lung cancer models and a window of opportunity trial in patients with lung cancer Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification.Ubiquitin specific protease 18 (Usp18) is a WT1 transcriptional target Interferon-stimulated gene 15 induces cancer cell death by suppressing the NF-κB signaling pathway.The ISG15-specific protease USP18 regulates stability of PTEN.Multiple functions of USP18.Analysis of apoptosis methods recently used in Cancer Research and Cell Death & Disease publications.PML: Regulation and multifaceted function beyond tumor suppression.Evidence for the ISG15-Specific Deubiquitinase USP18 as an Antineoplastic Target.Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer.

P2860

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P2860

Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARα and inhibits the growth of acute promyelocytic leukemia

http://www.wikidata.org/entity/Q34393733

description

2010 nî lūn-bûn

@nan

2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Blockade of the ubiquitin prot ...... f acute promyelocytic leukemia

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Blockade of the ubiquitin prot ...... f acute promyelocytic leukemia

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Blockade of the ubiquitin prot ...... f acute promyelocytic leukemia

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type

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Blockade of the ubiquitin prot ...... f acute promyelocytic leukemia

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Blockade of the ubiquitin prot ...... f acute promyelocytic leukemia

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Blockade of the ubiquitin prot ...... f acute promyelocytic leukemia

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Blockade of the ubiquitin prot ...... f acute promyelocytic leukemia

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Blockade of the ubiquitin prot ...... f acute promyelocytic leukemia

@en

Blockade of the ubiquitin prot ...... f acute promyelocytic leukemia

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0008-5472.CAN-10-1100

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Cancer Research

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Blockade of the ubiquitin prot ...... f acute promyelocytic leukemia

@en

P2093

Andrey V Dolinko

http://www.w3.org/2001/XMLSchema#string

Bruce Stanton

http://www.w3.org/2001/XMLSchema#string

Da-Cheng Zhou

http://www.w3.org/2001/XMLSchema#string

David Sekula

http://www.w3.org/2001/XMLSchema#string

Ethan Dmitrovsky

http://www.w3.org/2001/XMLSchema#string

Eugene Demidenko

http://www.w3.org/2001/XMLSchema#string

Fabrizio Galimberti

http://www.w3.org/2001/XMLSchema#string

Fadzai Chinyengetere

http://www.w3.org/2001/XMLSchema#string

Jennifer M Bomberger

http://www.w3.org/2001/XMLSchema#string

Robert Gallagher

http://www.w3.org/2001/XMLSchema#string

P2860

The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells

UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity

UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia

Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway.

UBP43 (USP18) specifically removes ISG15 from conjugated proteins.

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML

Modification of proteins by ubiquitin and ubiquitin-like proteins

The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

Ubiquitin and ubiquitin-like proteins as multifunctional signals

Screen for ISG15-crossreactive deubiquitinases.

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9875-9885

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scholarly article

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10.1158/0008-5472.CAN-10-1100

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23

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2010-10-08T00:00:00Z

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