Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway.
about
Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoproteinThe growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylasesLeukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodiesA novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory proteinA novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory proteinConjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus.UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemiaCloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genesThe role of the ubiquitination-proteasome pathway in breast cancer: applying drugs that affect the ubiquitin-proteasome pathway to the therapy of breast cancerCIViC databasePIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemiaRetinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteinsArsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemiaInterpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiationRetinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemiaThe disruption of ND10 during herpes simplex virus infection correlates with the Vmw110- and proteasome-dependent loss of several PML isoformsThe PML domain of PML-RARα blocks senescence to promote leukemiaRetinoid pathway and cancer therapeuticsBlockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARα and inhibits the growth of acute promyelocytic leukemiaAll-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemiaUBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylationInhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells.PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation.Intracellular localization of proteasomal degradation of a viral antigen.Posttranslational regulation of cyclin D1 by retinoic acid: a chemoprevention mechanismRetinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha) and oncogenic RARalpha fusion proteins.Auranofin promotes retinoic acid- or dihydroxyvitamin D3-mediated cell differentiation of promyelocytic leukaemia cells by increasing histone acetylation.Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cellsFournier's Gangrene Complicating Hematologic Malignancies: a Case Report and Review of Licterature.Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives.Retinoid receptor signaling and autophagy in acute promyelocytic leukemia.RARα2 and PML-RAR similarities in the control of basal and retinoic acid induced myeloid maturation of acute myeloid leukemia cellsTargeting fusion protein/corepressor contact restores differentiation response in leukemia cells.In vivo effects of a histone deacetylase inhibitor, FK228, on human acute promyelocytic leukemia in NOD / Shi-scid/scid mice.Spicamycin and KRN5500 induce apoptosis in myeloid and lymphoid cell lines with down-regulation of bcl-2 expression and modulation of promyelocytic leukemia protein.Specific destruction of kinetochore protein CENP-C and disruption of cell division by herpes simplex virus immediate-early protein Vmw110.All-trans retinoic acid and arsenic trioxide fail to derepress the monocytic differentiation driver Irf8 in acute promyelocytic leukemia cells.Alterations of specific chromatin conformation affect ATRA-induced leukemia cell differentiation.Retinoic acid and arsenic trioxide sensitize acute promyelocytic leukemia cells to ER stress.
P2860
Q22254766-3EEB9D8C-AFCC-435A-8BEF-FAE1944EF8A9Q24290948-D232CDD5-EE2B-4868-8F6F-B8824AFADE30Q24311314-6BD55107-2B31-4045-AA1C-B4C31DD88B43Q24532092-1FECD93C-D800-489B-8E76-23FE96205DF5Q24532134-3B46BB5C-3F40-4EFC-A52E-EB8B50417816Q24532901-54C1446B-14C7-4B51-BABE-9B3B6C611D27Q24533339-919CA985-0B6A-4F64-B434-B4FA81086EBAQ24655577-60D665AE-F11A-4C44-8F1C-26D8B03A4CCFQ24794927-259A28FE-0FAA-46FF-993E-79C678385974Q27612411-EF8DA3FB-F8DA-4258-953D-D8B2EA0BF611Q28343393-F74BDEE8-C228-4728-9A99-A310DAD9B9FEQ28344657-C0230748-73E6-44D5-9078-0F8AEEFB89CFQ28379542-A810E1A3-BDD2-4F1E-9212-19A1B1FA8C2FQ29616072-F833C284-8F07-4E87-882F-FAEEEC78E9FDQ33178068-72959488-9930-460B-9613-3B41A305C391Q33783492-D97B20DD-0824-47C3-80B2-06CC203522C3Q34082734-BC3A186F-DE2F-434F-B9D8-9C41742299B5Q34348117-07C866B1-33EB-4C89-A7C7-92FE862CE223Q34393733-223E531C-0A13-45B8-B946-E5EFB2C8AFD8Q34546653-8FC763A7-A7C5-4A71-B9C3-EE3CC6064F76Q34590516-758F3E2F-999F-4A65-8526-76B51222AE56Q34608747-A583F340-EBC4-413B-A53A-EFA2DB9E6F1AQ35950186-6FB6B7BC-95C2-4F5D-A2DF-8959CBCE6220Q36382090-FF906C67-AEB8-4DB6-9589-1B63EFFB86C2Q36635905-51E17962-51B8-40BD-BA20-890497F9B8E9Q36774571-275516DC-BCD3-4492-BB64-9BB181F509E6Q36790219-1823879C-6832-43DB-AB1E-58DB8258FDACQ37223322-6E560F93-679B-4C35-ABAF-C60DDC953751Q37358174-75684C8C-273D-4B94-A2CA-18F6A6F39C14Q37401665-D5FB5F38-7804-4621-9BB9-DA4CA5E47082Q37712353-28FA9944-7705-449B-A8C0-F0538CB4A9C0Q38201532-A9F7D6F1-B42B-4104-8577-3BAEB3F21791Q38758034-88925C9D-E728-466D-B1B8-000987B9E6AFQ40454835-A9BC3A8B-8951-4D44-9C12-01EFCB60AAE2Q40803071-2FAB9295-5A99-4671-BF8F-76F8CD0B1938Q40870715-88D7F6B2-7213-4D40-9902-A21CE857E7FAQ40967354-C6492AF6-2B20-4B7A-AB29-F77F0732C073Q41082633-7DCD8E58-A867-491C-9887-B1D3C1EF0208Q50106833-1C617E3C-A933-4C20-88F8-E30715FAB84CQ53730263-DEE0561D-E5F3-4E01-9D76-FEC75E468826
P2860
Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway.
description
1996 nî lūn-bûn
@nan
1996 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Accelerated degradation of PML ...... ole of the proteasome pathway.
@ast
Accelerated degradation of PML ...... ole of the proteasome pathway.
@en
Accelerated degradation of PML ...... ole of the proteasome pathway.
@nl
type
label
Accelerated degradation of PML ...... ole of the proteasome pathway.
@ast
Accelerated degradation of PML ...... ole of the proteasome pathway.
@en
Accelerated degradation of PML ...... ole of the proteasome pathway.
@nl
prefLabel
Accelerated degradation of PML ...... ole of the proteasome pathway.
@ast
Accelerated degradation of PML ...... ole of the proteasome pathway.
@en
Accelerated degradation of PML ...... ole of the proteasome pathway.
@nl
P2093
P3181
P356
P1433
P1476
Accelerated degradation of PML ...... ole of the proteasome pathway.
@en
P2093
K Kitamura
T Miyazaki
P304
P3181
P356
10.1038/SCIBX.2008.1066
P407
P577
1996-07-01T00:00:00Z