Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity
about
Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approachArtemisinin Action and Resistance in Plasmodium falciparumProfound activity of the anti-cancer drug bortezomib against Echinococcus multilocularis metacestodes identifies the proteasome as a novel drug target for cestodesTargeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistanceCharacterization of the 26S proteasome network in Plasmodium falciparumHigh-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinationsAssessing subunit dependency of the Plasmodium proteasome using small molecule inhibitors and active site probesIdentification of potent and selective non-covalent inhibitors of the Plasmodium falciparum proteasome.High-resolution cryo-EM proteasome structures in drug development.Identifying the Minimal Enzymes Required for Biosynthesis of Epoxyketone Proteasome Inhibitors.Structure- and function-based design of Plasmodium-selective proteasome inhibitorsThe cryo-EM structure of the Plasmodium falciparum 20S proteasome and its use in the fight against malaria.Targeting proteasomes in infectious organisms to combat disease.Proteases as antimalarial targets: strategies for genetic, chemical, and therapeutic validation.Protein Degradation Systems as Antimalarial Therapeutic Targets.Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity.Development of two novel high-throughput assays to quantify ubiquitylated proteins in cell lysates: application to screening of new anti-malarials.The Proteasome in Modern Drug Discovery: Second Life of a Highly Valuable Drug TargetRole of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan ParasitesRational Design of Proteasome Inhibitors as Antimalarial Drugs.Validation of Babesia proteasome as a drug targetAntimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance
P2860
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P2860
Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Validation of the proteasome a ...... ith parasite-specific toxicity
@ast
Validation of the proteasome a ...... ith parasite-specific toxicity
@en
Validation of the proteasome a ...... ith parasite-specific toxicity
@nl
type
label
Validation of the proteasome a ...... ith parasite-specific toxicity
@ast
Validation of the proteasome a ...... ith parasite-specific toxicity
@en
Validation of the proteasome a ...... ith parasite-specific toxicity
@nl
prefLabel
Validation of the proteasome a ...... ith parasite-specific toxicity
@ast
Validation of the proteasome a ...... ith parasite-specific toxicity
@en
Validation of the proteasome a ...... ith parasite-specific toxicity
@nl
P2093
P2860
P50
P1476
Validation of the proteasome a ...... ith parasite-specific toxicity
@en
P2093
Christopher J Kirk
Elizabeth L Ponder
Jeong Tae Lee
Kim C Williamson
Kristijana H Asbjornsdottir
Susan D Demo
P2860
P304
P356
10.1016/J.CHEMBIOL.2012.09.019
P577
2012-11-08T00:00:00Z