Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway. - Test2 - elhamkhani - TriplyDB

Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway.

Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway.

http://www.wikidata.org/entity/Q34561698

about

A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance Non-Canonical Hh Signaling in Cancer-Current Understanding and Future Directions The Role of Hedgehog Signaling in Tumor Induced Bone Disease Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy Basal cell carcinoma - molecular biology and potential new therapies Context-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapy Epidermal growth factor signaling in transformed cells Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors The Zfx gene is expressed in human gliomas and is important in the proliferation and apoptosis of the human malignant glioma cell line U251 DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance Compensatory pathways induced by MEK inhibition are effective drug targets for combination therapy against castration-resistant prostate cancer Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway.More than markers: biological significance of cancer stem cell-defining molecules.cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells.Gli1 promotes cell survival and is predictive of a poor outcome in ERalpha-negative breast cancer.Activation of the Hedgehog pathway in pilocytic astrocytomas.Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma A new tumour suppression mechanism by p27Kip1: EGFR down-regulation mediated by JNK/c-Jun pathway inhibition.Hepatitis C virus-mediated angiogenesis: molecular mechanisms and therapeutic strategies.Inactivation of Patched1 in mice leads to development of gastrointestinal stromal-like tumors that express Pdgfrα but not kit.Targeting Gli transcription activation by small molecule suppresses tumor growth.Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1 Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment.Regulation of sonic hedgehog expression by integrin β1 and epidermal growth factor receptor in intestinal epithelium Synergistic inhibition of colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002.Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia.The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer Inhibition of extracellular signal-regulated kinases ameliorates hypertension-induced renal vascular remodeling in rat models Endosulfan upregulates AP-1 binding and ARE-mediated transcription via ERK1/2 and p38 activation in HepG2 cells.Silibinin and its 2,3-dehydro-derivative inhibit basal cell carcinoma growth via suppression of mitogenic signaling and transcription factors activation.In vitro and in vivo antitumoral effects of combinations of polyphenols, or polyphenols and anticancer drugs: perspectives on cancer treatment Cooperative Hedgehog-EGFR signaling Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis.Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells Dynamic Bayesian Network Modeling of the Interplay between EGFR and Hedgehog Signaling.Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis.Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of Interleukin-6 and Vascular Endothelial Growth Factor A in Colon Cancer Cells and Induce Angiogenesis.

P2860

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P2860

Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway.

http://www.wikidata.org/entity/Q34561698

description

2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Epidermal growth factor recept ...... on of the MEK/ERK/JUN pathway.

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Epidermal growth factor recept ...... on of the MEK/ERK/JUN pathway.

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Epidermal growth factor recept ...... on of the MEK/ERK/JUN pathway.

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type

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Epidermal growth factor recept ...... on of the MEK/ERK/JUN pathway.

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Epidermal growth factor recept ...... on of the MEK/ERK/JUN pathway.

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Epidermal growth factor recept ...... on of the MEK/ERK/JUN pathway.

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Epidermal growth factor recept ...... on of the MEK/ERK/JUN pathway.

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Epidermal growth factor recept ...... on of the MEK/ERK/JUN pathway.

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Epidermal growth factor recept ...... on of the MEK/ERK/JUN pathway.

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0008-5472.CAN-08-2331

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Cancer Research

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Epidermal growth factor recept ...... on of the MEK/ERK/JUN pathway.

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Cornelia Hauser-Kronberger

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Doris Mangelberger

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Gerhard Regl

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Harald Schnidar

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Markus Eberl

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Renate Kroismayr

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Stefan Klingler

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P2860

Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling

MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin

Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.

Cell signaling by receptor tyrosine kinases

Untangling the ErbB signalling network

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1284-1292

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10.1158/0008-5472.CAN-08-2331

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4

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Richard Moriggl

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19190345

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3035872

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