about
Reconstitution of functional mycobacterial arabinosyltransferase AftC proteoliposome and assessment of decaprenylphosphorylarabinose analogues as arabinofuranosyl donorsNeed of cost-effective vaccines in developing countries: What plant biotechnology can offer?Translating basic science insight into public health action for multidrug- and extensively drug-resistant tuberculosisMycobacterium tuberculosis: success through dormancyTuberculosis: From an incurable scourge to a curable disease - journey over a millenniumStructure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline.Crystal Structure of Mycobacterium tuberculosis Zinc-dependent Metalloprotease-1 (Zmp1), a Metalloprotease Involved in PathogenicityThe Apo-structure of the Low Molecular Weight Protein-tyrosine Phosphatase A (MptpA) from Mycobacterium tuberculosis Allows for Better Target-specific Drug DevelopmentStructure of Streptomyces Maltosyltransferase GlgE, a Homologue of a Genetically Validated Anti-tuberculosis TargetMechanism-based Inactivation by Aromatization of the Transaminase BioA Involved in Biotin Biosynthesis in Mycobaterium tuberculosisPiperidinols That Show Anti-Tubercular Activity as Inhibitors of Arylamine N-Acetyltransferase: An Essential Enzyme for Mycobacterial Survival Inside MacrophagesCrystal structure of L,D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosisCarbohydrate Recognition by RpfB from Mycobacterium tuberculosis Unveiled by Crystallographic and Molecular Dynamics AnalysesOptimization of Pyrrolamides as Mycobacterial GyrB ATPase Inhibitors: Structure-Activity Relationship and In Vivo Efficacy in a Mouse Model of TuberculosisStructure and Inhibition of Tuberculosinol Synthase and Decaprenyl Diphosphate Synthase from Mycobacterium tuberculosisTowards a new combination therapy for tuberculosis with next generation benzothiazinonesMolecular determinants of inactivation of the resuscitation promoting factor B from Mycobacterium tuberculosisApplication of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121Structural Insight into How Streptomyces coelicolor Maltosyl Transferase GlgE Binds α-Maltose 1-Phosphate and Forms a Maltosyl-enzyme IntermediateNew target prediction and visualization tools incorporating open source molecular fingerprints for TB Mobile 2.0Purification and proteomics of pathogen-modified vacuoles and membranesFirst-in-Class Inhibitors of Sulfur Metabolism with Bactericidal Activity against Non-Replicating M. tuberculosisNew insights into TB physiology suggest untapped therapeutic opportunitiesProbing the interaction of the diarylquinoline TMC207 with its target mycobacterial ATP synthaseActivity of trifluoperazine against replicating, non-replicating and drug resistant M. tuberculosisNitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosisModeling phenotypic metabolic adaptations of Mycobacterium tuberculosis H37Rv under hypoxiaIdentification of novel imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrBTetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3Octanoylation of early intermediates of mycobacterial methylglucose lipopolysaccharidesHigh throughput screen identifies small molecule inhibitors specific for Mycobacterium tuberculosis phosphoserine phosphataseEnhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian modelsCharacterisation of ATP-dependent Mur ligases involved in the biogenesis of cell wall peptidoglycan in Mycobacterium tuberculosisIn vitro and in vivo activities of ruthenium(II) phosphine/diimine/picolinate complexes (SCAR) against Mycobacterium tuberculosisRv0132c of Mycobacterium tuberculosis encodes a coenzyme F420-dependent hydroxymycolic acid dehydrogenaseResource competition may lead to effective treatment of antibiotic resistant infectionsHypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanismMycobacteria counteract a TLR-mediated nitrosative defense mechanism in a zebrafish infection modelBiochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug targetInhibition of a Putative Dihydropyrimidinase from Pseudomonas aeruginosa PAO1 by Flavonoids and Substrates of Cyclic Amidohydrolases
P2860
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P2860
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The challenge of new drug discovery for tuberculosis.
@en
The challenge of new drug discovery for tuberculosis.
@nl
type
label
The challenge of new drug discovery for tuberculosis.
@en
The challenge of new drug discovery for tuberculosis.
@nl
prefLabel
The challenge of new drug discovery for tuberculosis.
@en
The challenge of new drug discovery for tuberculosis.
@nl
P2093
P2860
P356
P1433
P1476
The challenge of new drug discovery for tuberculosis.
@en
P2093
Eric Arnoult
Jerome Guillemont
Koen Andries
Nacer Lounis
P2860
P2888
P304
P356
10.1038/NATURE09657
P407
P577
2011-01-01T00:00:00Z
P5875
P6179
1033892653