Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity. - Test2 - elhamkhani - TriplyDB

Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity.

Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity.

http://www.wikidata.org/entity/Q34695519

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Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer's NFTs Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease Therapeutic and diagnostic challenges for frontotemporal dementia I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain.Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients.Mechanisms of tau-induced neurodegeneration.Protein tau: prime cause of synaptic and neuronal degeneration in Alzheimer's disease.Cytoplasmic retention of protein phosphatase 2A inhibitor 2 (I2PP2A) induces Alzheimer-like abnormal hyperphosphorylation of Tau.Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease.Age related changes in pancreatic beta cells: A putative extra-cerebral site of Alzheimer's pathology.Tau in Alzheimer disease and related tauopathies.Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial Developing pharmacological therapies for Alzheimer disease.Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention.Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level.Are tangles as toxic as they look?Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment.Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration.Neuroprotection: lessons from hibernators.Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions.Novel therapeutic strategies for the treatment of protein-misfolding diseases.The importance of tau phosphorylation for neurodegenerative diseases Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.Tau aggregation in Alzheimer's disease: what role for phosphorylation?The role of tau in neurodegeneration Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases.Cytosolic abnormally hyperphosphorylated tau but not paired helical filaments sequester normal MAPs and inhibit microtubule assembly Tau pathology is present in vivo and develops in vitro in sensory neurons from human P301S tau transgenic mice: a system for screening drugs against tauopathies Does Alzheimer's disease begin in the brainstem?The role of tau in Alzheimer's disease and related disorders.Intracellular and extracellular tau.Mitochondrial dysfunction as a therapeutic target in progressive supranuclear palsy.Modulation of GSK-3 as a Therapeutic Strategy on Tau Pathologies.Recent rodent models for Alzheimer's disease: clinical implications and basic research.Understanding the relationship between GSK-3 and Alzheimer's disease: a focus on how GSK-3 can modulate synaptic plasticity processes.Autophagy modulation for Alzheimer's disease therapy.

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P2860

Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity.

http://www.wikidata.org/entity/Q34695519

description

2006 nî lūn-bûn

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2006年の論文

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name

Polymerization of hyperphospho ...... nates its inhibitory activity.

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Polymerization of hyperphospho ...... nates its inhibitory activity.

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Polymerization of hyperphospho ...... nates its inhibitory activity.

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Polymerization of hyperphospho ...... nates its inhibitory activity.

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Polymerization of hyperphospho ...... nates its inhibitory activity.

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Polymerization of hyperphospho ...... nates its inhibitory activity.

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Polymerization of hyperphospho ...... nates its inhibitory activity.

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Polymerization of hyperphospho ...... nates its inhibitory activity.

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Polymerization of hyperphospho ...... nates its inhibitory activity.

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Polymerization of hyperphospho ...... nates its inhibitory activity.

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Alejandra del C Alonso

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P2860

A protein factor essential for microtubule assembly

Tau is enriched on dynamic microtubules in the distal region of growing axons

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

Tau suppression in a neurodegenerative mouse model improves memory function

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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Inge Grundke-Iqbal

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