Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments - Test2 - elhamkhani - TriplyDB

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

http://www.wikidata.org/entity/Q24599152

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Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease Histone deacetylase 6 interacts with the microtubule-associated protein tau Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century Selective interaction of lansoprazole and astemizole with tau polymers: potential new clinical use in diagnosis of Alzheimer's disease Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease NMR Meets Tau: Insights into Its Function and Pathology Nuclear Tau and Its Potential Role in Alzheimer's Disease Targeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitors Lithium and autophagy Tangles, Toxicity, and Tau Secretion in AD - New Approaches to a Vexing Problem The role of tau in neurodegenerative diseases and its potential as a therapeutic target Functional O-GlcNAc modifications: implications in molecular regulation and pathophysiology Proteolytic cleavage of apolipoprotein E4 as the keystone for the heightened risk associated with Alzheimer's disease Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro.The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation (-)-SCR1693 Protects against Memory Impairment and Hippocampal Damage in a Chronic Cerebral Hypoperfusion Rat Model Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8 Dietary Phytochemicals in Neuroimmunoaging: A New Therapeutic Possibility for Humans?Neuroprotective Mechanisms Mediated by CDK5 Inhibition Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system Propofol directly increases tau phosphorylation Proteomic identification of protein targets for 15-deoxy-Δ(12,14)-prostaglandin J2 in neuronal plasma membrane Rapid changes in phospho-MAP/tau epitopes during neuronal stress: cofilin-actin rods primarily recruit microtubule binding domain epitopes Altered regulation of Akt signaling with murine cerebral malaria, effects on long-term neuro-cognitive function, restoration with lithium treatment Discovery of dihydrochalcone as potential lead for Alzheimer's disease: in silico and in vitro study Evolutionary constraint and disease associations of post-translational modification sites in human genomes I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A Nucleation-dependent tau filament formation: the importance of dimerization and an estimation of elementary rate constants β-Amyloid impairs axonal BDNF retrograde trafficking.Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling.Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro.Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain.Hyperphosphorylation of JNK-interacting protein 1, a protein associated with Alzheimer disease.Conformational changes and cleavage of tau in Pick bodies parallel the early processing of tau found in Alzheimer pathology.Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice Dysregulation of tau phosphorylation in mouse brain during excitotoxic damage

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Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

http://www.wikidata.org/entity/Q24599152

description

2001 nî lūn-bûn

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2001 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2001 թվականի հունիսին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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Hyperphosphorylation induces s ...... l filaments/straight filaments

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Hyperphosphorylation induces s ...... l filaments/straight filaments

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Hyperphosphorylation induces s ...... l filaments/straight filaments

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Hyperphosphorylation induces s ...... l filaments/straight filaments

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Hyperphosphorylation induces s ...... l filaments/straight filaments

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Hyperphosphorylation induces s ...... l filaments/straight filaments

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Hyperphosphorylation induces s ...... l filaments/straight filaments

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Hyperphosphorylation induces s ...... l filaments/straight filaments

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Hyperphosphorylation induces s ...... l filaments/straight filaments

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Proceedings of the National Academy of Sciences of the United States of America

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Hyperphosphorylation induces s ...... l filaments/straight filaments

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P2093

A Alonso

http://www.w3.org/2001/XMLSchema#string

I Grundke-Iqbal

http://www.w3.org/2001/XMLSchema#string

K Iqbal

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M Novak

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T Zaidi

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P2860

DNA sequencing with chain-terminating inhibitors

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease

Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

Hyperphosphorylation of tau in PHF

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

A nucleated assembly mechanism of Alzheimer paired helical filaments.

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6923-8

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scholarly article

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437178

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10.1073/PNAS.121119298

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12

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98

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2001-06-05T00:00:00Z

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11958027

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11381127

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34454

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