Direct involvement of the TEN domain at the active site of human telomerase - Test2 - elhamkhani - TriplyDB

Direct involvement of the TEN domain at the active site of human telomerase

Direct involvement of the TEN domain at the active site of human telomerase

http://www.wikidata.org/entity/Q34699797

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Finding the end: recruitment of telomerase to telomeres ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis Identification of human TERT elements necessary for telomerase recruitment to telomeres.Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase.Human telomerase: biogenesis, trafficking, recruitment, and activation.A mutation in the catalytic subunit of yeast telomerase alters primer-template alignment while promoting processivity and protein-DNA binding.Telomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase.Human telomerase model shows the role of the TEN domain in advancing the double helix for the next polymerization step.A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase.The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA-DNA hybrids.Telomeric G-quadruplexes are a substrate and site of localization for human telomerase Single-molecule imaging of telomerase reverse transcriptase in human telomerase holoenzyme and minimal RNP complexes.Telomerase recruitment requires both TCAB1 and Cajal bodies independently.A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization.An intact putative mouse telomerase essential N-terminal domain is necessary for proper telomere maintenance.Single-Molecule Studies of Telomeres and Telomerase.Telomere biology and telomerase mutations in cirrhotic patients with hepatocellular carcinoma.Human telomerase specialization for repeat synthesis by unique handling of primer-template duplex.A web of interactions at the ends.Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding.DNA-binding determinants and cellular thresholds for human telomerase repeat addition processivity.Structure and function of the N-terminal domain of the yeast telomerase reverse transcriptase.

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P2860

Direct involvement of the TEN domain at the active site of human telomerase

http://www.wikidata.org/entity/Q34699797

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Direct involvement of the TEN domain at the active site of human telomerase

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Direct involvement of the TEN domain at the active site of human telomerase

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Direct involvement of the TEN domain at the active site of human telomerase

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type

label

Direct involvement of the TEN domain at the active site of human telomerase

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Direct involvement of the TEN domain at the active site of human telomerase

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Direct involvement of the TEN domain at the active site of human telomerase

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prefLabel

Direct involvement of the TEN domain at the active site of human telomerase

@ast

Direct involvement of the TEN domain at the active site of human telomerase

@en

Direct involvement of the TEN domain at the active site of human telomerase

@nl

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Nucleic Acids Research

P1476

Direct involvement of the TEN domain at the active site of human telomerase

@en

P2093

Amanda S Nouwens

http://www.w3.org/2001/XMLSchema#string

George O Lovrecz

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Julie Jurczyluk

http://www.w3.org/2001/XMLSchema#string

Scott B Cohen

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Tracy M Bryan

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P2860

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1

Human telomerase contains evolutionarily conserved catalytic and structural subunits

PROCHECK: a program to check the stereochemical quality of protein structures

An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization

Nucleolar localization of hTERT protein is associated with telomerase function

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

Human telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivo

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1774-1788

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scholarly article

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10.1093/NAR/GKQ1083

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5

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39

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Michael W Parker

Timothy E Adams

Jessica K Holien

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2010-11-03T00:00:00Z

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47678941

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21051362

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3061064

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