about
Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108VThiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2Manipulating the Lewis antigen specificity of the cholesterol-dependent cytolysin lectinolysinStructure of the Lectin Regulatory Domain of the Cholesterol-Dependent Cytolysin Lectinolysin Reveals the Basis for Its Lewis Antigen SpecificityDirect involvement of the TEN domain at the active site of human telomeraseDisarming bacterial virulence through chemical inhibition of the DNA binding domain of an AraC-like transcriptional activator protein.Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1).Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation.Molecular and structural insight into lysine selection on substrate and ubiquitin lysine 48 by the ubiquitin-conjugating enzyme Cdc34In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza viruses.Oncogenic protein interfaces: small molecules, big challenges.The C-terminal extension of human telomerase reverse transcriptase is necessary for high affinity binding to telomeric DNA.Improvements, trends, and new ideas in molecular docking: 2012-2013 in review.Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase.A homodimer model can resolve the conundrum as to how cytochrome P450 oxidoreductase and cytochrome b5 compete for the same binding site on cytochrome P450c17.A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development.Control of Virulence Gene Expression by the Master Regulator, CfaD, in the Prototypical Enterotoxigenic Escherichia coli Strain, H10407.Evolutionary comparisons predict that dimerization of human cytochrome P450 aromatase increases its enzymatic activity and efficiency.Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor.Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding.AMP and adenosine are both ligands for adenosine 2B receptor signaling.An Activation-Specific Platelet Inhibitor That Can Be Turned On/Off by Medically Used Hypothermia
P50
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P50
description
investigador
@es
researcher
@en
name
Jessica K Holien
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type
label
Jessica K Holien
@en
prefLabel
Jessica K Holien
@en
P31
P496
0000-0002-8735-2871