Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1 - Test2 - elhamkhani - TriplyDB

Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1

Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1

http://www.wikidata.org/entity/Q24603295

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Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates POT1 association with TRF2 regulates telomere length Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro POT1 and TRF2 cooperate to maintain telomeric integrity Multiple facets of TPP1 in telomere maintenance Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain Switching human telomerase on and off with hPOT1 protein in vitro Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation Functional interaction between telomere protein TPP1 and telomerase Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis Identification of human TERT elements necessary for telomerase recruitment to telomeres.Human telomerase: biogenesis, trafficking, recruitment, and activation.Distinct requirements for Pot1 in limiting telomere length and maintaining chromosome stability The Arabidopsis Pot1 and Pot2 proteins function in telomere length homeostasis and chromosome end protection Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase alpha.Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance.Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation.Distinct functions of POT1 at telomeres.Utility of telomerase-pot1 fusion protein in vascular tissue engineering.Structural and functional analysis of the human POT1-TPP1 telomeric complex.Pot1 and telomere maintenance.Expression of (NES-)hTERT in cancer cells delays cell cycle progression and increases sensitivity to genotoxic stress A small molecule inhibitor of Pot1 binding to telomeric DNA.Relevance and safety of telomerase for human tissue engineering.Caenorhabditis elegans POT-1 and POT-2 repress telomere maintenance pathways.Direct involvement of the TEN domain at the active site of human telomerase Characterization of physical and functional anchor site interactions in human telomerase.Telomerase: a potential therapeutic target for cancer.Telomerase recruitment requires both TCAB1 and Cajal bodies independently.Function, replication and structure of the mammalian telomere Chromosome end maintenance by telomerase.Structure-function relationships in telomerase genes.Endogenous Telomerase Reverse Transcriptase N-Terminal Tagging Affects Human Telomerase Function at Telomeres In Vivo.An intact putative mouse telomerase essential N-terminal domain is necessary for proper telomere maintenance.

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Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1

http://www.wikidata.org/entity/Q24603295

description

2004 nî lūn-bûn

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2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2004 թվականի ապրիլին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1

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Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1

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Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1

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type

label

Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1

@ast

Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1

@en

Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1

@nl

prefLabel

Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1

@ast

Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1

@en

Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1

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MCB.24.8.3552-3561.2004

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Molecular and Cellular Biology

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Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1

@en

P2093

Blaine N Armbruster

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Christopher M Counter

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Corinne M Linardic

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Diane L Downie

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Niharika P Bansal

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Tim Veldman

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P2860

Mammalian telomeres end in a large duplex loop

POT1 as a terminal transducer of TRF1 telomere length control

Human POT1 facilitates telomere elongation by telomerase

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

Control of telomere length by the human telomeric protein TRF1

Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing

Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding

Control of human telomere length by TRF1 and TRF2

Conserved structure for single-stranded telomeric DNA recognition

Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA

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