The PC6B cytoplasmic domain contains two acidic clusters that direct sorting to distinct trans-Golgi network/endosomal compartments.
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The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modificationsA PACS-1, GGA3 and CK2 complex regulates CI-MPR traffickingProprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi networkVACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic.The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein trafficFurin at the cutting edge: from protein traffic to embryogenesis and diseaseThe cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi networkDynamic tracking and mobility analysis of single GLUT4 storage vesicle in live 3T3-L1 cells.Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouseTrans-Golgi network sorting.The mammalian Golgi--complex debates.A di-leucine sequence and a cluster of acidic amino acids are required for dynamic retention in the endosomal recycling compartment of fibroblasts.At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis.An acidic motif retains vesicular monoamine transporter 2 on large dense core vesicles.Site-specific cleavage of BMP4 by furin, PC6, and PC7.Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4.Structure-function analysis of the prosegment of the proprotein convertase PC5A.RNAi-mediated silencing of prohormone convertase (PC) 5/6 expression leads to impairment in processing of cocaine- and amphetamine-regulated transcript (CART) precursor.Coated pit-mediated endocytosis of the type I transforming growth factor-β (TGF-β) receptor depends on a di-leucine family signal and is not required for signaling.Internalization of proprotein convertase PC7 from plasma membrane is mediated by a novel motif.Selective and signal-dependent recruitment of membrane proteins to secretory granules formed by heterologously expressed von Willebrand factor.The C-terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro.The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases.Endothelial lipase is inactivated upon cleavage by the members of the proprotein convertase family.Molecular determinants for PICK1 synaptic aggregation and mGluR7a receptor coclustering: role of the PDZ, coiled-coil, and acidic domains.Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme.Dynamic palmitoylation of lymphoma proprotein convertase prolongs its half-life, but is not essential for trans-Golgi network localization.The cytosolic C-terminus of the glucose transporter GLUT4 contains an acidic cluster endosomal targeting motif distal to the dileucine signal.Sorting of carboxypeptidase E to the regulated secretory pathway requires interaction of its transmembrane domain with lipid raftsCytoplasmic envelopment of human cytomegalovirus requires the postlocalization function of tegument protein pp28 within the assembly compartment.Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage.Profibrillin-1 maturation by human dermal fibroblasts: proteolytic processing and molecular chaperones.Access of a membrane protein to secretory granules is facilitated by phosphorylation.Ectodomain shedding of furin: kinetics and role of the cysteine-rich region.An acidic cluster of the cytoplasmic tail of the RD114 virus glycoprotein controls assembly of retroviral envelopes.Proprotein convertase genes in Xenopus development.The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates.The proprotein convertase SKI-1/S1P: alternate translation and subcellular localization.Membrane association domains in Ca2+-dependent activator protein for secretion mediate plasma membrane and dense-core vesicle binding required for Ca2+-dependent exocytosis.
P2860
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P2860
The PC6B cytoplasmic domain contains two acidic clusters that direct sorting to distinct trans-Golgi network/endosomal compartments.
description
2000 nî lūn-bûn
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2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2000 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
The PC6B cytoplasmic domain co ...... etwork/endosomal compartments.
@ast
The PC6B cytoplasmic domain co ...... etwork/endosomal compartments.
@en
The PC6B cytoplasmic domain co ...... etwork/endosomal compartments.
@nl
type
label
The PC6B cytoplasmic domain co ...... etwork/endosomal compartments.
@ast
The PC6B cytoplasmic domain co ...... etwork/endosomal compartments.
@en
The PC6B cytoplasmic domain co ...... etwork/endosomal compartments.
@nl
prefLabel
The PC6B cytoplasmic domain co ...... etwork/endosomal compartments.
@ast
The PC6B cytoplasmic domain co ...... etwork/endosomal compartments.
@en
The PC6B cytoplasmic domain co ...... etwork/endosomal compartments.
@nl
P2093
P2860
P356
P1476
The PC6B cytoplasmic domain co ...... etwork/endosomal compartments.
@en
P2093
P2860
P304
P356
10.1091/MBC.11.4.1257
P577
2000-04-01T00:00:00Z