Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain.
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A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's diseaseMetabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion proteinSynaptic Cell Adhesion Molecules in Alzheimer's DiseaseAmyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer diseaseHijacking PrP(c)-dependent signal transduction: when prions impair Aβ clearanceInsoluble cellular prion protein and its association with prion and Alzheimer diseasesAlzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons.Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.Therapeutic molecules and endogenous ligands regulate the interaction between brain cellular prion protein (PrPC) and metabotropic glutamate receptor 5 (mGluR5).Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo.Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.Synthetic Aβ peptides acquire prion-like properties in the brain.Characterization of spontaneously generated prion-like conformers in cultured cells.Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death.Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models.Isolation of soluble and insoluble PrP oligomers in the normal human brain.Pathogenic prions deviate PrP(C) signaling in neuronal cells and impair A-beta clearanceThe complex PrP(c)-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease.Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's diseaseSoluble prion protein and its N-terminal fragment prevent impairment of synaptic plasticity by Aβ oligomers: Implications for novel therapeutic strategy in Alzheimer's disease.The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers.Prions: Beyond a Single Protein.Quiescin-sulfhydryl oxidase inhibits prion formation in vitro.Fyn kinase inhibition as a novel therapy for Alzheimer's disease.Allosteric function and dysfunction of the prion protein.Interaction between pathogenic proteins in neurodegenerative disorders.Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease.Overcoming barriers and thresholds - signaling of oligomeric Aβ through the prion protein to Fyn.Biophysical studies of the amyloid β-peptide: interactions with metal ions and small molecules.Taking advantage of physiological proteolytic processing of the prion protein for a therapeutic perspective in prion and Alzheimer diseases.The cellular prion protein (PrPC) as neuronal receptor for α-synuclein.Cross-interactions between the Alzheimer Disease Amyloid-β Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis.S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation.Unraveling the neuroprotective mechanisms of PrP (C) in excitotoxicity.Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons.High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer's disease.Liquid and Hydrogel Phases of PrP Linked to Conformation Shifts and Triggered by Alzheimer's Amyloid-β OligomersProtein Co-Aggregation Related to Amyloids: Methods of Investigation, Diversity, and Classification
P2860
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P2860
Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain.
@ast
Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain.
@en
Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain.
@nl
type
label
Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain.
@ast
Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain.
@en
Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain.
@nl
prefLabel
Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain.
@ast
Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain.
@en
Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain.
@nl
P2093
P2860
P356
P1476
Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain.
@en
P2093
Diego E Rincon-Limas
Geoff Kneale
Gianfranco Puoti
Hisashi Fujioka
Hyoung-gon Lee
Jian-Ping Guo
John McGeehan
Patrick L McGeer
Pedro Fernandez-Funez
P2860
P304
15095-15105
P356
10.1074/JBC.M110.199356
P407
P577
2011-03-10T00:00:00Z