ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage. - Test2 - elhamkhani - TriplyDB

ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage.

ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage.

http://www.wikidata.org/entity/Q34987777

about

Chromatin perturbations during the DNA damage response in higher eukaryotes Cellular and cell-free studies of catalytic DNA cleavage by ruthenium polypyridyl complexes containing redox-active intercalating ligands.Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells.The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo.Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation.Anti-tumor activity of the ATR inhibitor AZD6738 in HER2 positive breast cancer cells.Inhibiting Mitochondrial DNA Ligase IIIα Activates Caspase 1-Dependent Apoptosis in Cancer Cells LC-MS/MS assay for the simultaneous quantitation of the ATM inhibitor AZ31 and the ATR inhibitor AZD6738 in mouse plasma.Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19.Mismatch repair enhances convergent transcription-induced cell death at trinucleotide repeats by activating ATR.Radiosensitization of human leukemic HL-60 cells by ATR kinase inhibitor (VE-821): phosphoproteomic analysis.Simian virus 40 large T antigen induces IFN-stimulated genes through ATR kinase.TIMELESS Suppresses the Accumulation of Aberrant CDC45·MCM2-7·GINS Replicative Helicase Complexes on Human Chromatin.Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1.Regulation of human polλ by ATM-mediated phosphorylation during non-homologous end joining.APE2 promotes DNA damage response pathway from a single-strand break.A novel role for ATR/Rad3 in G1 phase.

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P2860

ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage.

http://www.wikidata.org/entity/Q34987777

description

2013 nî lūn-bûn

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2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

ATR kinase activation in G1 ph ...... radiation-induced DNA damage.

@ast

ATR kinase activation in G1 ph ...... radiation-induced DNA damage.

@en

ATR kinase activation in G1 ph ...... radiation-induced DNA damage.

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type

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ATR kinase activation in G1 ph ...... radiation-induced DNA damage.

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ATR kinase activation in G1 ph ...... radiation-induced DNA damage.

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ATR kinase activation in G1 ph ...... radiation-induced DNA damage.

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ATR kinase activation in G1 ph ...... radiation-induced DNA damage.

@ast

ATR kinase activation in G1 ph ...... radiation-induced DNA damage.

@en

ATR kinase activation in G1 ph ...... radiation-induced DNA damage.

@nl

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Nucleic Acids Research

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ATR kinase activation in G1 ph ...... radiation-induced DNA damage.

@en

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Christopher J Bakkenist

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Joel S Greenberger

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Reza Rofougaran

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Simon C Watkins

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P2860

Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

The DNA Damage Response: Making It Safe to Play with Knives

Human CtIP mediates cell cycle control of DNA end resection and double strand break repair

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

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