Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
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Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatinNOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpointPCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.Geminin promotes neural fate acquisition of embryonic stem cells by maintaining chromatin in an accessible and hyperacetylated statePrevention of DNA re-replication in eukaryotic cellsReplication licensing and cancer--a fatal entanglement?Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phaseMechanisms to control rereplication and implications for cancer.DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrestDNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1Size sensors in bacteria, cell cycle control, and size controlRegulation of Unperturbed DNA Replication by UbiquitylationGenomic instability in cancer.Sequential replication-coupled destruction at G1/S ensures genome stability.Cycle inhibiting factors (cifs): cyclomodulins that usurp the ubiquitin-dependent degradation pathway of host cells.Functional dissection of the catalytic carboxyl-terminal domain of origin recognition complex subunit 1 (PfORC1) of the human malaria parasite Plasmodium falciparumRegulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome StabilityDistinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4BCDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiationThe tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progressionCell cycle-regulated protein abundance changes in synchronously proliferating HeLa cells include regulation of pre-mRNA splicing proteinsAccelerated protein evolution analysis reveals genes and pathways associated with the evolution of mammalian longevityUSP37 deubiquitinates Cdt1 and contributes to regulate DNA replicationRecruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachmentDeregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.Disruption of cyclin D1 nuclear export and proteolysis accelerates mammary carcinogenesisAurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis.Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factorCRL4Cdt2: master coordinator of cell cycle progression and genome stabilityAcetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1.The APC/C inhibitor, Emi1, is essential for prevention of rereplicationIlluminating cell-cycle progression in the developing zebrafish embryo.RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteinsComplex cell cycle abnormalities caused by human T-lymphotropic virus type 1 Tax.DDB1 maintains genome integrity through regulation of Cdt1Proliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cells.
P2860
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P2860
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis
@nl
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
@ast
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
@en
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
@en-gb
type
label
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis
@nl
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
@ast
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
@en
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
@en-gb
prefLabel
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis
@nl
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
@ast
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
@en
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
@en-gb
P2093
P2860
P50
P3181
P356
P1433
P1476
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis
@en
P2093
Chikashi Obuse
Keiichi I Nakayama
Keiko Nakayama
Masafumi Saijo
Takeharu Nishimoto
Toshiki Tsurimoto
Yohsuke Nakanishi
Zoi Lygerou
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7601002
P407
P577
2006-02-16T00:00:00Z