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Function, regulation and pathological roles of the Gab/DOS docking proteinsRoles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factorBivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative mannerA novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activationPhosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking proteinGAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signalingCell signaling by receptor tyrosine kinasesGrb2-associated binding (Gab) proteins in hematopoietic and immune cell biologyA novel role for Gab2 in bFGF-mediated cell survival during retinoic acid-induced neuronal differentiationRecent updates of precision therapy for gastric cancer: Towards optimal tailored managementRegulation of Endothelial Adherens Junctions by Tyrosine PhosphorylationEMT-Inducing Molecular Factors in Gynecological CancersGAB2--a scaffolding protein in cancerStructure and function of Gab2 and its role in cancer (Review)Functions and regulation of circular dorsal rufflesOncogenic Signaling Adaptor ProteinsGab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-KitPak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptorB-cell receptor signalling and its crosstalk with other pathways in normal and malignant cellsOrder and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategiesRAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumorsThe Gab2 in signal transduction and its potential role in the pathogenesis of Alzheimer's diseaseCXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells.Novel inhibitors induce large conformational changes of GAB1 pleckstrin homology domain and kill breast cancer cellsInsulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cellsT-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiationGab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motilityCoactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapiesAllostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner.Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration.The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans.Host adaptor proteins Gab1 and CrkII promote InlB-dependent entry of Listeria monocytogenes.grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice.The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold.Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo.Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation.A transgenic Drosophila model demonstrates that the Helicobacter pylori CagA protein functions as a eukaryotic Gab adaptor.Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function.Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric control
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The "Gab" in signal transduction.
@ast
The "Gab" in signal transduction.
@en
type
label
The "Gab" in signal transduction.
@ast
The "Gab" in signal transduction.
@en
prefLabel
The "Gab" in signal transduction.
@ast
The "Gab" in signal transduction.
@en
P1476
The "Gab" in signal transduction
@en
P2093
P304
P356
10.1016/S0962-8924(03)00002-3
P577
2003-03-01T00:00:00Z