Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo.
about
Evolution of pre-existing versus acquired resistance to platinum drugs and PARP inhibitors in BRCA-associated cancersUbiquitin E3 ligase CRL4(CDT2/DCAF2) as a potential chemotherapeutic target for ovarian surface epithelial cancerDeletion of Arid1a in Reproductive Tract Mesenchymal Cells Reduces Fertility in Female Mice.FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development.The loss of Hoxa5 function causes estrous acyclicity and ovarian epithelial inclusion cysts.Proteomic profiling of a mouse model for ovarian granulosa cell tumor identifies VCP as a highly sensitive serum tumor marker in several human cancers.Death induced by CD95 or CD95 ligand elimination.MUC1 positive, Kras and Pten driven mouse gynecologic tumors replicate human tumors and vary in survival and nuclear grade based on anatomical location.A genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high-grade serous carcinoma development.Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models.Global deletion of Trp53 reverts ovarian tumor phenotype of the germ cell-deficient white spotting variant (Wv) mice.The insulin-like growth factor 1 pathway is a potential therapeutic target for low-grade serous ovarian carcinoma.High-grade serous ovarian cancer arises from fallopian tube in a mouse model.Wild-type tumor repressor protein 53 (Trp53) promotes ovarian cancer cell survival.Minireview: animal models and mechanisms of ovarian cancer development.Consequences of RAS and MAPK activation in the ovary: the good, the bad and the ugly.Dysregulation of mitotic machinery genes precedes genome instability during spontaneous pre-malignant transformation of mouse ovarian surface epithelial cells.Tumorigenesis and peritoneal colonization from fallopian tube epithelium.Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival.PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progression.Death domain-associated protein DAXX promotes ovarian cancer development and chemoresistance.Evaluating the progenitor cells of ovarian cancer: analysis of current animal models.Mutant p53 Promotes Epithelial Ovarian Cancer by Regulating Tumor Differentiation, Metastasis, and Responsiveness to Steroid Hormones.Follicle Depletion Provides a Permissive Environment for Ovarian Carcinogenesis.Induction of estrogen-sensitive epithelial cells derived from human-induced pluripotent stem cells to repair ovarian function in a chemotherapy-induced mouse model of premature ovarian failureTumor repressor protein 53 and steroid hormones provide a new paradigm for ovarian cancer metastases.Immunobiology of human mucin 1 in a preclinical ovarian tumor model.Recent technological advances in using mouse models to study ovarian cancer.Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer.Through the glass darkly: intraepithelial neoplasia, top-down differentiation, and the road to ovarian cancer.Epithelial ovarian cancer experimental models.Role of microRNAs in cancers of the female reproductive tract: insights from recent clinical and experimental discovery studies.Early transformative changes in normal ovarian surface epithelium induced by oxidative stress require Akt upregulation, DNA damage and epithelial-stromal interaction.Thy-1+ Cancer-associated Fibroblasts Adversely Impact Lung Cancer Prognosis.Impact of oviductal versus ovarian epithelial cell of origin on ovarian endometrioid carcinoma phenotype in the mouse.Chemotherapy-Induced Depletion of OCT4-Positive Cancer Stem Cells in a Mouse Model of Malignant Testicular Cancer.Sequential molecular changes and dynamic oxidative stress in high-grade serous ovarian carcinogenesis.A mouse model for endometrioid ovarian cancer arising from the distal oviduct.The Endometriotic Tumor Microenvironment in Ovarian Cancer
P2860
Q28542563-7C791733-4E85-49C2-BFC6-4849E1B5FC72Q28674964-316E2BDA-F1BD-4946-AE44-7301EED8244CQ30353348-9EB3F7A7-CD23-4355-BDC0-E705B82FF6F9Q30358011-537AFABE-0491-4D46-8CB7-6626C59B1598Q30422138-C82B2DA9-7749-426F-9859-DE6D30E77C3DQ30425624-85104005-36C5-4F6A-A193-01CFF45BF7ADQ30582837-A19B5310-761C-4CE0-9BB6-509BD5AC2DF1Q33981906-0401640E-B259-457E-B304-5DEB24AF762DQ34111959-64E51F83-D48B-4DFD-AA4D-7D77C8D74B65Q34391423-7761BD78-3CC1-4D24-8B63-9ED7C861BF10Q35024049-F0E9DBA0-7670-4DA0-A002-B212F9458F12Q35209365-A647E09F-8007-4419-86C1-34EEB64C5FB3Q35844827-B224CCA5-D290-450B-88C5-2A9ED7F28D5AQ35872729-7A6B30A6-0250-43BF-AF03-849059601B2FQ35872732-E5FCAE3C-9924-439B-99AE-A81689C19A14Q35892495-F675754B-B4F0-40E1-B3F6-F6069638EC45Q36179026-8E09B7EF-EB68-421E-9559-D26F3E43EC27Q36299733-FD4FED59-D65C-481C-A746-12864738DD1AQ36309603-21A476C2-18DE-486E-A266-0626F35F11DBQ36740722-9B5F18E9-934D-4EA1-88B1-52785E77D723Q36832656-BF9C36F4-1314-4928-AE00-CACE1D8460A8Q36916354-575385F3-8B70-4415-A9DC-B3D4B71CF72BQ36917897-6E921F11-235B-4E44-AB5A-E09826228320Q37224153-FCAD58D3-C22E-4D82-A1D4-9BA44B630CB8Q37395293-686BA976-38FE-40EF-B29E-FC12A4DC1368Q37417687-6988DA11-1637-4392-9A09-83EDF9536452Q37527861-CFFE584B-9377-491D-9E37-822B8472A0D6Q37581537-1AEC93C8-444E-41C4-8091-DA388A0B3961Q37616060-CFB13BB1-8286-4020-A7F6-92C70EFA84ADQ37626525-5564AF2D-597A-467B-A9C4-D5522412D735Q37708938-D230C130-74E0-4D59-901B-B6187CC490D0Q38258014-B894A1DB-ED94-41EF-A5FE-3044437A446AQ39214181-CFF1368E-6A74-4BC3-8931-6DF1505569CDQ41125664-B1EAE2DA-0E34-4E44-AFE4-7EA208A9EBB1Q42671513-5699E545-B7A4-41E8-8430-995A995BAA0EQ44899713-0D1A197B-B630-4C13-95EA-C856D9855B7DQ46303839-A5C6A3CF-6373-4FF6-89A4-E55FD1378F16Q54296090-5EAB756C-92BE-432F-914B-03B182ABF754Q58796878-38F57959-B00F-4E09-A75B-EB1FBD202B87
P2860
Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Molecular and functional chara ...... Pten in a mouse model in vivo.
@ast
Molecular and functional chara ...... Pten in a mouse model in vivo.
@en
type
label
Molecular and functional chara ...... Pten in a mouse model in vivo.
@ast
Molecular and functional chara ...... Pten in a mouse model in vivo.
@en
prefLabel
Molecular and functional chara ...... Pten in a mouse model in vivo.
@ast
Molecular and functional chara ...... Pten in a mouse model in vivo.
@en
P2093
P2860
P50
P356
P1433
P1476
Molecular and functional chara ...... Pten in a mouse model in vivo
@en
P2093
C J Creighton
J S Richards
L K Mullany
P Gunaratne
P2860
P2888
P304
P356
10.1038/ONC.2011.70
P407
P577
2011-03-21T00:00:00Z