Ubiquitin E3 ligase CRL4(CDT2/DCAF2) as a potential chemotherapeutic target for ovarian surface epithelial cancer - Test2 - elhamkhani - TriplyDB

Ubiquitin E3 ligase CRL4(CDT2/DCAF2) as a potential chemotherapeutic target for ovarian surface epithelial cancer

Ubiquitin E3 ligase CRL4(CDT2/DCAF2) as a potential chemotherapeutic target for ovarian surface epithelial cancer

http://www.wikidata.org/entity/Q28674964

about

The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B Ubiquitylation, neddylation and the DNA damage response CRL4-DCAF1 ubiquitin E3 ligase directs protein phosphatase 2A degradation to control oocyte meiotic maturation.Integrative analysis of multi-omics data reveals distinct impacts of DDB1-CUL4 associated factors in human lung adenocarcinomas.The role of cullin4B in human cancers.The stress phenotype makes cancer cells addicted to CDT2, a substrate receptor of the CRL4 ubiquitin ligase.Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death It is not all about BRCA: Cullin-Ring ubiquitin Ligases in ovarian cancer.DNA damage-induced activation of CUL4B targets HUWE1 for proteasomal degradation.p27 Stands-up-to-cancer: UPS nuclear service stops Suppression of tumor angiogenesis by targeting the protein neddylation pathway.Circadian clock components RORα and Bmal1 mediate the anti-proliferative effect of MLN4924 in osteosarcoma cells.SCF ubiquitin ligase-targeted therapies.MLN4924 therapy as a novel approach in cancer treatment modalities.Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer.Targeting the protein ubiquitination machinery in melanoma by the NEDD8-activating enzyme inhibitor pevonedistat (MLN4924).TET1 inhibits cell proliferation by inducing RASSF5 expression.Maternal DCAF2 is crucial for maintenance of genome stability during the first cell cycle in mice.CRL4DCAF1 is required in activated oocytes for follicle maintenance and ovulation.Neddylation inhibitor MLN4924 induces G2 cell cycle arrest, DNA damage and sensitizes esophageal squamous cell carcinoma cells to cisplatin.Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis.A functional genomics screen reveals a strong synergistic effect between docetaxel and the mitotic gene DLGAP5 that is mediated by the androgen receptor

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P2860

Ubiquitin E3 ligase CRL4(CDT2/DCAF2) as a potential chemotherapeutic target for ovarian surface epithelial cancer

http://www.wikidata.org/entity/Q28674964

description

2013 nî lūn-bûn

@nan

2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2013 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Ubiquitin E3 ligase CRL4(CDT2/ ...... rian surface epithelial cancer

@ast

Ubiquitin E3 ligase CRL4(CDT2/ ...... rian surface epithelial cancer

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Ubiquitin E3 ligase CRL4(CDT2/ ...... rian surface epithelial cancer

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type

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Ubiquitin E3 ligase CRL4(CDT2/ ...... rian surface epithelial cancer

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Ubiquitin E3 ligase CRL4(CDT2/ ...... rian surface epithelial cancer

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Ubiquitin E3 ligase CRL4(CDT2/ ...... rian surface epithelial cancer

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prefLabel

Ubiquitin E3 ligase CRL4(CDT2/ ...... rian surface epithelial cancer

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Ubiquitin E3 ligase CRL4(CDT2/ ...... rian surface epithelial cancer

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Ubiquitin E3 ligase CRL4(CDT2/ ...... rian surface epithelial cancer

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JBC.M113.495069

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Journal of Biological Chemistry

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Ubiquitin E3 ligase CRL4(CDT2/ ...... rian surface epithelial cancer

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Chao Yu

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Fang-Zhou Song

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Hai-Yi Zhang

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Heng-Yu Fan

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Jian-Jie Zhou

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Lian-Jun Guo

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Wei-Wei Pan

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Ying Xu

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P2860

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase

Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis

VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation

Genetic abolishment of hepatocyte proliferation activates hepatic stem cells

Tumor-prone phenotype of the DDB2-deficient mice

CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis.

DCAF26, an adaptor protein of Cul4-based E3, is essential for DNA methylation in Neurospora crassa.

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29680-91

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scholarly article

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10.1074/JBC.M113.495069

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