Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters.
about
Monoamine transporters: insights from molecular dynamics simulationsDesigning modulators of monoamine transporters using virtual screening techniquesHow LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transportersStructural basis for action by diverse antidepressants on biogenic amine transportersExploring the Inhibitory Mechanism of Approved Selective Norepinephrine Reuptake Inhibitors and Reboxetine Enantiomers by Molecular Dynamics StudyX-ray structures and mechanism of the human serotonin transporter.Monoamine transporter structure, function, dynamics, and drug discovery: a computational perspective.The solute carrier 6 family of transportersSteric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporterA rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter.Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding SitesDesign and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites.Binding-induced fluorescence of serotonin transporter ligands: A spectroscopic and structural study of 4-(4-(dimethylamino)phenyl)-1-methylpyridinium (APP(+)) and APP(+) analogues.New design strategies for antidepressant drugs.Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5-HT transporterBinding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporterImportance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation.Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket.Structure and Dynamics Study of LeuT Using the Markov State Model and Perturbation Response Scanning Reveals Distinct Ion Induced Conformational States.Structural basis for recognition of diverse antidepressants by the human serotonin transporter.Copper-catalysed cyanoalkylative cycloetherification of alkenes to 1,3-dihydroisobenzofurans: development and application to the synthesis of citalopram.
P2860
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P2860
Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年学术文章
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2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
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2011年学术文章
@zh-sg
2011年學術文章
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name
Molecular determinants for sel ...... d norepinephrine transporters.
@ast
Molecular determinants for sel ...... d norepinephrine transporters.
@en
type
label
Molecular determinants for sel ...... d norepinephrine transporters.
@ast
Molecular determinants for sel ...... d norepinephrine transporters.
@en
prefLabel
Molecular determinants for sel ...... d norepinephrine transporters.
@ast
Molecular determinants for sel ...... d norepinephrine transporters.
@en
P2093
P2860
P356
P1476
Molecular determinants for sel ...... d norepinephrine transporters.
@en
P2093
Anders S Kristensen
Andrew D Bond
Benny Bang-Andersen
Jacob Andersen
Jonas N N Eildal
Klaus P Bøgesø
Kristian Strømgaard
Linda Zachariassen
Nicolai Stuhr-Hansen
Stinna M R Hansen
P2860
P304
12137-12142
P356
10.1073/PNAS.1103060108
P407
P577
2011-07-05T00:00:00Z