A competitive inhibitor traps LeuT in an open-to-out conformation.
about
X-ray structure of dopamine transporter elucidates antidepressant mechanismAntidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structuresA current view of serotonin transportersMonoamine transporters: insights from molecular dynamics simulationsInsights to ligand binding to the monoamine transporters-from homology modeling to LeuBAT and dDATDesigning modulators of monoamine transporters using virtual screening techniquesVisualizing functional motions of membrane transporters with molecular dynamics simulationsBehavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporterNonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substratesHow LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transportersSpontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminusA steered molecular dynamics study of binding and translocation processes in the GABA transporterA conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state.Neurotransmitter and psychostimulant recognition by the dopamine transporter.Complete mapping of substrate translocation highlights the role of LeuT N-terminal segment in regulating transport cycleModeling and dynamics of the inward-facing state of a Na+/Cl- dependent neurotransmitter transporter homologueAlternating Access in Maltose Transporter Mediated by Rigid-Body RotationsBinding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformationStructure and Mechanism of a Na+-Independent Amino Acid TransporterMolecular Basis of Alternating Access Membrane Transport by the Sodium-Hydantoin Transporter Mhp1The mechanism of sodium and substrate release from the binding pocket of vSGLTCrystal structure of the maltose transporter in a pretranslocation intermediate stateSubstrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologueInsights into transport mechanism from LeuT engineered to transport tryptophanX-ray structures of LeuT in substrate-free outward-open and apo inward-open statesStructures of LeuT in bicelles define conformation and substrate binding in a membrane-like contextStructural basis for action by diverse antidepressants on biogenic amine transportersMolecular mechanism of ligand recognition by membrane transport protein, Mhp1The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitorsLigand induced conformational changes of the human serotonin transporter revealed by molecular dynamics simulationsAmino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2)Novel molecular targets of dezocine and their clinical implicationsDirect assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMRExploring the Inhibitory Mechanism of Approved Selective Norepinephrine Reuptake Inhibitors and Reboxetine Enantiomers by Molecular Dynamics StudySystematic comparison of molecular conformations of H+,K+-ATPase reveals an important contribution of the A-M2 linker for the luminal gating.A conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporterA gate-free pathway for substrate release from the inward-facing state of the Na⁺-galactose transporterMutations in the GlyT2 gene (SLC6A5) are a second major cause of startle disease.Shape-Dependent Global Deformation Modes of Large Protein StructuresStructural insights into the activation mechanism of melibiose permease by sodium binding.
P2860
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P2860
A competitive inhibitor traps LeuT in an open-to-out conformation.
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
A Competitive Inhibitor Traps LeuT in an Open-to-Out Conformation
@nl
A competitive inhibitor traps LeuT in an open-to-out conformation.
@ast
A competitive inhibitor traps LeuT in an open-to-out conformation.
@en
type
label
A Competitive Inhibitor Traps LeuT in an Open-to-Out Conformation
@nl
A competitive inhibitor traps LeuT in an open-to-out conformation.
@ast
A competitive inhibitor traps LeuT in an open-to-out conformation.
@en
prefLabel
A Competitive Inhibitor Traps LeuT in an Open-to-Out Conformation
@nl
A competitive inhibitor traps LeuT in an open-to-out conformation.
@ast
A competitive inhibitor traps LeuT in an open-to-out conformation.
@en
P2093
P2860
P3181
P356
P1433
P1476
A competitive inhibitor traps LeuT in an open-to-out conformation.
@en
P2093
Atsuko Yamashita
Chayne L Piscitelli
Eric Gouaux
Satinder K Singh
P2860
P304
P3181
P356
10.1126/SCIENCE.1166777
P407
P50
P577
2008-12-01T00:00:00Z