Incidence and persistence of 8-oxo-7,8-dihydroguanine within a hairpin intermediate exacerbates a toxic oxidation cycle associated with trinucleotide repeat expansion
about
Tumor-specific microsatellite instability: do distinct mechanisms underlie the MSI-L and EMAST phenotypes?Ups and Downs: Mechanisms of Repeat Instability in the Fragile X-Related DisordersAPE1 incision activity at abasic sites in tandem repeat sequencesInstability of CTG repeats is governed by the position of a DNA base lesion through base excision repairBase excision repair of tandem modifications in a methylated CpG dinucleotide.Premutation huntingtin allele adopts a non-B conformation and contains a hot spot for DNA damage.Trinucleotide repeat DNA alters structure to minimize the thermodynamic impact of 8-oxo-7,8-dihydroguanine.Repeat instability during DNA repair: Insights from model systemsAP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair.Instability of (CTG)n•(CAG)n trinucleotide repeats and DNA synthesisDNA base excision repair: a mechanism of trinucleotide repeat expansion.The nucleotide sequence, DNA damage location, and protein stoichiometry influence the base excision repair outcome at CAG/CTG repeatsRate-determining Step of Flap Endonuclease 1 (FEN1) Reflects a Kinetic Bias against Long Flaps and Trinucleotide Repeat Sequences.Base excision repair in physiology and pathology of the central nervous systemUnique Length-Dependent Biophysical Properties of Repetitive DNA.Modulation of base excision repair of 8-oxoguanine by the nucleotide sequenceSteady-state, pre-steady-state, and single-turnover kinetic measurement for DNA glycosylase activity.A brief history of triplet repeat diseases.Impact of bulge loop size on DNA triplet repeat domains: Implications for DNA repair and expansion.Abnormal base excision repair at trinucleotide repeats associated with diseases: a tissue-selective mechanism.Proliferating cell nuclear antigen prevents trinucleotide repeat expansions by promoting repeat deletion and hairpin removal.Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion.Chemical and biological consequences of oxidatively damaged guanine in DNA.The yin and yang of repair mechanisms in DNA structure-induced genetic instability.DNA repair mechanisms in Huntington's disease.Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instabilityA chemical and kinetic perspective on base excision repair of DNA.Energy landscapes of dynamic ensembles of rolling triplet repeat bulge loops: implications for DNA expansion associated with disease states.An oxidized abasic lesion inhibits base excision repair leading to DNA strand breaks in a trinucleotide repeat tract.
P2860
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P2860
Incidence and persistence of 8-oxo-7,8-dihydroguanine within a hairpin intermediate exacerbates a toxic oxidation cycle associated with trinucleotide repeat expansion
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Incidence and persistence of 8 ...... trinucleotide repeat expansion
@ast
Incidence and persistence of 8 ...... trinucleotide repeat expansion
@en
type
label
Incidence and persistence of 8 ...... trinucleotide repeat expansion
@ast
Incidence and persistence of 8 ...... trinucleotide repeat expansion
@en
prefLabel
Incidence and persistence of 8 ...... trinucleotide repeat expansion
@ast
Incidence and persistence of 8 ...... trinucleotide repeat expansion
@en
P2093
P2860
P1433
P1476
Incidence and persistence of 8 ...... trinucleotide repeat expansion
@en
P2093
Daniel A Jarem
Kelly M Schermerhorn
Nicole R Wilson
Sarah Delaney
P2860
P304
P356
10.1016/J.DNAREP.2011.06.003
P577
2011-07-02T00:00:00Z